Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1704313..1704967 Replicon chromosome
Accession NZ_CP074112
Organism Idiomarina loihiensis strain SN11

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KGF88_RS08175 Protein ID WP_110076065.1
Coordinates 1704313..1704672 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KGF88_RS08180 Protein ID WP_110076064.1
Coordinates 1704665..1704967 (+) Length 101 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KGF88_RS08160 (KGF88_08185) 1699958..1700602 - 645 WP_153825959.1 response regulator transcription factor -
KGF88_RS08165 (KGF88_08190) 1700695..1702638 - 1944 WP_153825960.1 acetate--CoA ligase -
KGF88_RS08170 (KGF88_08195) 1703011..1704189 + 1179 WP_153825961.1 DcaP family trimeric outer membrane transporter -
KGF88_RS08175 (KGF88_08200) 1704313..1704672 + 360 WP_110076065.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KGF88_RS08180 (KGF88_08205) 1704665..1704967 + 303 WP_110076064.1 helix-turn-helix transcriptional regulator Antitoxin
KGF88_RS08185 (KGF88_08210) 1705042..1705629 - 588 WP_110076063.1 hypothetical protein -
KGF88_RS08190 (KGF88_08215) 1705626..1706837 - 1212 WP_162014454.1 transglycosylase SLT domain-containing protein -
KGF88_RS08195 (KGF88_08220) 1706791..1707519 - 729 WP_153825963.1 hypothetical protein -
KGF88_RS08200 (KGF88_08225) 1707519..1708790 - 1272 WP_162014455.1 hypothetical protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(12-106)

Antitoxin

(32-84)


Sequences


Toxin        


Download         Length: 120 a.a.        Molecular weight: 13627.56 Da        Isoelectric Point: 7.8823

>T201468 WP_110076065.1 NZ_CP074112:1704313-1704672 [Idiomarina loihiensis]
MWTIRTTDRFDAWFDALDDTDKENVIASLLLLQSEGPFLSRPYADTLYGSVHSNLKELRIQSKGKPIRVCFAFDLSRTAI
ILCAAHKNRNTRLFYQTMIATADQEFTRHLIAMGQKDNG

Download         Length: 360 bp

>T201468 NZ_CP098439:98228-98533 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 10982.88 Da        Isoelectric Point: 9.6858

>AT201468 WP_110076064.1 NZ_CP074112:1704665-1704967 [Idiomarina loihiensis]
MARTLEQLIANEKPELIARASKKADAMLLTIRLSEIRKLVNKTQVDLANSMGIKQPTVAGMEKTGADIKLSSLKKYIEAC
GAHLKVDIELPDGSHHQFSL

Download         Length: 303 bp

>AT201468 NZ_CP098439:98008-98226 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References