Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4563091..4563872 | Replicon | chromosome |
| Accession | NZ_CP074098 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain C_cip | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | A0A3G3E5T9 |
| Locus tag | KFV01_RS22035 | Protein ID | WP_000625911.1 |
| Coordinates | 4563381..4563872 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | V7IUD2 |
| Locus tag | KFV01_RS22030 | Protein ID | WP_001271379.1 |
| Coordinates | 4563091..4563384 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV01_RS21995 (4558702) | 4558702..4559607 | + | 906 | WP_001268192.1 | YjiK family protein | - |
| KFV01_RS22000 (4559946) | 4559946..4560404 | + | 459 | WP_000502119.1 | IS200/IS605-like element IS200F family transposase | - |
| KFV01_RS22005 (4560613) | 4560613..4560882 | - | 270 | WP_010989096.1 | hypothetical protein | - |
| KFV01_RS22010 (4560890) | 4560890..4561105 | - | 216 | WP_001595136.1 | hypothetical protein | - |
| KFV01_RS22015 (4561128) | 4561128..4561415 | - | 288 | WP_072103482.1 | transcriptional regulator RtsB | - |
| KFV01_RS22020 (4561412) | 4561412..4562287 | - | 876 | WP_023205266.1 | AraC family transcriptional regulator | - |
| KFV01_RS22025 (4562553) | 4562553..4562774 | - | 222 | WP_212634550.1 | hypothetical protein | - |
| KFV01_RS22030 (4563091) | 4563091..4563384 | + | 294 | WP_001271379.1 | DUF1778 domain-containing protein | Antitoxin |
| KFV01_RS22035 (4563381) | 4563381..4563872 | + | 492 | WP_000625911.1 | GNAT family N-acetyltransferase | Toxin |
| KFV01_RS22040 (4564120) | 4564120..4564872 | - | 753 | WP_023205271.1 | non-specific acid phosphatase | - |
| KFV01_RS22045 (4564963) | 4564963..4565049 | - | 87 | Protein_4314 | porin family protein | - |
| KFV01_RS22050 (4566081) | 4566081..4566458 | - | 378 | WP_000916345.1 | EthD family reductase | - |
| KFV01_RS22055 (4566530) | 4566530..4566862 | + | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| KFV01_RS22065 (4567306) | 4567306..4567881 | - | 576 | WP_001188509.1 | transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| flank | IS/Tn | - | - | 4559946..4560404 | 458 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17663.44 Da Isoelectric Point: 7.2655
>T201456 WP_000625911.1 NZ_CP074098:4563381-4563872 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T201456 NZ_CP098438:c1039172-1038645 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTGCAACGCCATGCACGACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATGTTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATACGATGTGCCGGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGTGGCGTAGCCCTACTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10938.54 Da Isoelectric Point: 9.8590
>AT201456 WP_001271379.1 NZ_CP074098:4563091-4563384 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT201456 NZ_CP098438:c1039459-1039169 [Salmonella enterica subsp. enterica serovar Typhimurium]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGGCTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACATACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGCGATACTAAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G3E5T9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V7IUD2 |