Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4563143..4563924 Replicon chromosome
Accession NZ_CP074096
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 2B_cip

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag KFV00_RS22035 Protein ID WP_000625911.1
Coordinates 4563433..4563924 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag KFV00_RS22030 Protein ID WP_001271379.1
Coordinates 4563143..4563436 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV00_RS21995 (4558755) 4558755..4559660 + 906 WP_001268192.1 YjiK family protein -
KFV00_RS22000 (4559999) 4559999..4560457 + 459 WP_000502119.1 IS200/IS605-like element IS200F family transposase -
KFV00_RS22005 (4560666) 4560666..4560935 - 270 WP_010989096.1 hypothetical protein -
KFV00_RS22010 (4560943) 4560943..4561158 - 216 WP_212634368.1 hypothetical protein -
KFV00_RS22015 (4561181) 4561181..4561468 - 288 WP_072103482.1 transcriptional regulator RtsB -
KFV00_RS22020 (4561465) 4561465..4562340 - 876 WP_023205266.1 AraC family transcriptional regulator -
KFV00_RS22025 (4562605) 4562605..4562826 - 222 WP_052939504.1 hypothetical protein -
KFV00_RS22030 (4563143) 4563143..4563436 + 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
KFV00_RS22035 (4563433) 4563433..4563924 + 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
KFV00_RS22040 (4564180) 4564180..4564932 - 753 WP_023205271.1 non-specific acid phosphatase -
KFV00_RS22045 (4565023) 4565023..4565109 - 87 Protein_4314 porin family protein -
KFV00_RS22050 (4566141) 4566141..4566518 - 378 WP_000916345.1 EthD family reductase -
KFV00_RS22055 (4566590) 4566590..4566922 + 333 WP_001165471.1 MerR family transcriptional regulator -
KFV00_RS22060 (4567046) 4567046..4567090 + 45 WP_079827815.1 hypothetical protein -
KFV00_RS22070 (4567361) 4567361..4567936 - 576 WP_001188509.1 transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 4559999..4560457 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T201432 WP_000625911.1 NZ_CP074096:4563433-4563924 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T201432 NZ_CP098408:c1646641-1646378 [Alcaligenes sp. DN25]
ATGACTGACCGTTTGTTATGCTGGACTGACGCTGCCTGGATTGACTATGTGTATTGGCAAGGCCAGGACCGCAAGACATT
GAAGCGTATCAACAGACTGATAGAGGAAGTACGACGTGCGCCATTCGATGGCATAGGCAAACCTGAAGCGCTTAAAGAAA
ATCTGTCCGGCTTTTGGTCAAGACGCATTGATGACACGAATCGCCTGGTCTATGCCGTAGACAAGGCAAGCATCACCATC
ATTTCTTGTCGTTATCATTATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT201432 WP_001271379.1 NZ_CP074096:4563143-4563436 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT201432 NZ_CP098408:c1646888-1646634 [Alcaligenes sp. DN25]
ATGAAAATCATCTCGTTTTCAGAAGCGCGCAACAGCTTGAAAGCTGTACTGGATAGCGTAGTCGATGACGCCAGCACCAC
CATCATCACGCGTCGTGATGCGGAAGACGCTGTAGTCATGTCACTCGATTACTACAACAGCTTGATGGAAACCGTCCATC
TGCTGCGCTCCCCCGCTAATGCGGAACACCTGAGCCGCTCTATCGAACAATATCGTGCTGGCAAAGCCATGCCACGCGAG
CTGAGCGATGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References