Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 4240191..4240945 | Replicon | chromosome |
| Accession | NZ_CP074096 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain 2B_cip | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | B5F003 |
| Locus tag | KFV00_RS20595 | Protein ID | WP_000558166.1 |
| Coordinates | 4240634..4240945 (-) | Length | 104 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | KFV00_RS20590 | Protein ID | WP_001259011.1 |
| Coordinates | 4240191..4240637 (-) | Length | 149 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV00_RS20560 (4235367) | 4235367..4236263 | + | 897 | WP_001520529.1 | sugar kinase | - |
| KFV00_RS20565 (4236297) | 4236297..4237100 | + | 804 | WP_000059693.1 | DeoR/GlpR family DNA-binding transcription regulator | - |
| KFV00_RS20570 (4237291) | 4237291..4237890 | + | 600 | WP_000965695.1 | glucose-1-phosphatase | - |
| KFV00_RS20575 (4237884) | 4237884..4238756 | + | 873 | WP_000921423.1 | virulence factor BrkB family protein | - |
| KFV00_RS20580 (4238753) | 4238753..4239190 | + | 438 | WP_000560969.1 | D-aminoacyl-tRNA deacylase | - |
| KFV00_RS20585 (4239235) | 4239235..4240176 | + | 942 | WP_001518251.1 | fatty acid biosynthesis protein FabY | - |
| KFV00_RS20590 (4240191) | 4240191..4240637 | - | 447 | WP_001259011.1 | type II toxin-antitoxin system HigA family antitoxin | Antitoxin |
| KFV00_RS20595 (4240634) | 4240634..4240945 | - | 312 | WP_000558166.1 | type II toxin-antitoxin system HigB family toxin | Toxin |
| KFV00_RS20600 (4241031) | 4241031..4241960 | - | 930 | WP_212634352.1 | alpha/beta hydrolase | - |
| KFV00_RS20605 (4242178) | 4242178..4242489 | + | 312 | WP_023138876.1 | hypothetical protein | - |
| KFV00_RS20610 (4242490) | 4242490..4242780 | + | 291 | WP_000362052.1 | DNA-binding transcriptional regulator | - |
| KFV00_RS20615 (4242827) | 4242827..4243756 | - | 930 | WP_000027730.1 | formate dehydrogenase accessory protein FdhE | - |
| KFV00_RS20620 (4243753) | 4243753..4244388 | - | 636 | WP_000829025.1 | formate dehydrogenase cytochrome b556 subunit | - |
| KFV00_RS20625 (4244385) | 4244385..4245287 | - | 903 | WP_000331361.1 | formate dehydrogenase subunit beta | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 104 a.a. Molecular weight: 12432.40 Da Isoelectric Point: 9.5334
>T201430 WP_000558166.1 NZ_CP074096:c4240945-4240634 [Salmonella enterica subsp. enterica serovar Typhimurium]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE
Download Length: 312 bp
>T201430 NZ_CP098403:1549345-1549608 [Lactobacillus kefiranofaciens subsp. kefirgranum]
ATGCTAAGTTGGACTGATGATGGCTGTGACGACTACTTGAATTGGCAAAAGCAAAGGCAGAAAAAGAAAATAAAACGTAT
CAACAAATTAATTACAGACATTAAACGTCATCCCTTTGAAGGAATGGGCAAACCGGAAGGCTTAAAGAATAATCTAACAG
GCTTATGGTCTCGTAAAATTGATGCTAAAAACAGAATTATTTATGAGTATACAAATGAGAACGTTATAATCTATTCCTGC
AAAGATCATTATGATGACCATTAA
ATGCTAAGTTGGACTGATGATGGCTGTGACGACTACTTGAATTGGCAAAAGCAAAGGCAGAAAAAGAAAATAAAACGTAT
CAACAAATTAATTACAGACATTAAACGTCATCCCTTTGAAGGAATGGGCAAACCGGAAGGCTTAAAGAATAATCTAACAG
GCTTATGGTCTCGTAAAATTGATGCTAAAAACAGAATTATTTATGAGTATACAAATGAGAACGTTATAATCTATTCCTGC
AAAGATCATTATGATGACCATTAA
Antitoxin
Download Length: 149 a.a. Molecular weight: 16734.08 Da Isoelectric Point: 6.6451
>AT201430 WP_001259011.1 NZ_CP074096:c4240637-4240191 [Salmonella enterica subsp. enterica serovar Typhimurium]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE
Download Length: 447 bp
>AT201430 NZ_CP098403:1549074-1549361 [Lactobacillus kefiranofaciens subsp. kefirgranum]
ATGGATGCTGTAAACTATAGTAATTTTAGAAAAGATTTAAAAACCTACTTTAAGCAAGTAAACGATGATAGTGAGCCTTT
GATTGTAACTAATAAAAATCCAGAAGATAATGTCGTTGTCTTAAGCAAAGATGAATATGACGCTTTAATAGAAACCTTGG
CAATTCAATCTAATAAATATCTAATGGATAAAATTAATCGTGGACGCAAGCAAGTAGCTAAAGCACAAACTAATCAACAT
GAACTAATTGATCCAGATGGCGAGGTATCAGATGCTAAGTTGGACTGA
ATGGATGCTGTAAACTATAGTAATTTTAGAAAAGATTTAAAAACCTACTTTAAGCAAGTAAACGATGATAGTGAGCCTTT
GATTGTAACTAATAAAAATCCAGAAGATAATGTCGTTGTCTTAAGCAAAGATGAATATGACGCTTTAATAGAAACCTTGG
CAATTCAATCTAATAAATATCTAATGGATAAAATTAATCGTGGACGCAAGCAAGTAGCTAAAGCACAAACTAATCAACAT
GAACTAATTGATCCAGATGGCGAGGTATCAGATGCTAAGTTGGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|