Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 3680094..3680632 Replicon chromosome
Accession NZ_CP074096
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain 2B_cip

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag KFV00_RS17985 Protein ID WP_001526148.1
Coordinates 3680094..3680369 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag KFV00_RS17990 Protein ID WP_000729713.1
Coordinates 3680372..3680632 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV00_RS17980 (3677296) 3677296..3680001 + 2706 WP_212634333.1 HTH-type transcriptional regulator MalT -
KFV00_RS17985 (3680094) 3680094..3680369 - 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
KFV00_RS17990 (3680372) 3680372..3680632 - 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
KFV00_RS17995 (3680741) 3680741..3681760 - 1020 WP_212634334.1 RNA 3'-terminal phosphate cyclase -
KFV00_RS18000 (3681764) 3681764..3682978 - 1215 WP_001105526.1 RNA-splicing ligase RtcB -
KFV00_RS18010 (3683325) 3683325..3683516 - 192 Protein_3537 TROVE domain-containing protein -
KFV00_RS18015 (3683525) 3683525..3685078 - 1554 WP_000013015.1 TROVE domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T201427 WP_001526148.1 NZ_CP074096:c3680369-3680094 [Salmonella enterica subsp. enterica serovar Typhimurium]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T201427 NZ_CP098400:1430314-1430613 [Alkaliflexus sp. Ai-910]
ATGTATATAATTGAGAAGACAGAAGAATTTGACAAATGGCTGAGAAAACTTAAAGATTTAAGAGCCAAAGCCAAAATATT
GTTTCGTATTCAAAAGATTGAGAATGATGAACACTTTGGCGACTGCAAACTTGTTGGGAATGGTATTCGGGAGTTGAAAA
TTGACTTTGCTAAAGGATACAGGGTATACTTTAAAGAATCTGACGGAAAAATCATTATCCTGCTTATTGGTGGAGATAAA
TCAACTCAGCAGAGAGACATTGAAAAGGCAAAAGAGATTTTAAAACGAATTAAAAAGTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT201427 WP_000729713.1 NZ_CP074096:c3680632-3680372 [Salmonella enterica subsp. enterica serovar Typhimurium]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT201427 NZ_CP098400:1430618-1430902 [Alkaliflexus sp. Ai-910]
ATGGGAACATCAAAATTTGATATAGCTGACTATTTAGATAGTAACGAGATGATTGCTGAATATCTTAATACTGTTTTAGC
AGAGGGAAACGAAGCCGATGTAATTGTAGCTATTGGACATATAGCAAAATCAATCGGCATGACCAAAATTGCTCAAGAAA
CTGGATTAAGTAGGACAAGTTTATACAAAGCTTTATCGGAAGGTGCAAAACCTCAGTTTGAGACGATTATGAAAGTATTA
AAAGCAATAGGCGGACAGATACAAATAAATCCCATGAATGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References