Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4562943..4563724 | Replicon | chromosome |
| Accession | NZ_CP074094 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain A_cip | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | A0A3G3E5T9 |
| Locus tag | KFU99_RS22040 | Protein ID | WP_000625911.1 |
| Coordinates | 4563233..4563724 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | V7IUD2 |
| Locus tag | KFU99_RS22035 | Protein ID | WP_001271379.1 |
| Coordinates | 4562943..4563236 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFU99_RS22000 (4558554) | 4558554..4559459 | + | 906 | WP_001268192.1 | YjiK family protein | - |
| KFU99_RS22005 (4559798) | 4559798..4560256 | + | 459 | WP_000502119.1 | IS200/IS605-like element IS200F family transposase | - |
| KFU99_RS22010 (4560465) | 4560465..4560734 | - | 270 | WP_010989096.1 | hypothetical protein | - |
| KFU99_RS22015 (4560742) | 4560742..4560957 | - | 216 | WP_001595136.1 | hypothetical protein | - |
| KFU99_RS22020 (4560980) | 4560980..4561267 | - | 288 | WP_072103482.1 | transcriptional regulator RtsB | - |
| KFU99_RS22025 (4561264) | 4561264..4562139 | - | 876 | WP_023205266.1 | AraC family transcriptional regulator | - |
| KFU99_RS22030 (4562405) | 4562405..4562626 | - | 222 | WP_212634550.1 | hypothetical protein | - |
| KFU99_RS22035 (4562943) | 4562943..4563236 | + | 294 | WP_001271379.1 | DUF1778 domain-containing protein | Antitoxin |
| KFU99_RS22040 (4563233) | 4563233..4563724 | + | 492 | WP_000625911.1 | GNAT family N-acetyltransferase | Toxin |
| KFU99_RS22045 (4563972) | 4563972..4564724 | - | 753 | WP_023205271.1 | non-specific acid phosphatase | - |
| KFU99_RS22050 (4564827) | 4564827..4564901 | - | 75 | Protein_4312 | porin family protein | - |
| KFU99_RS22055 (4565933) | 4565933..4566310 | - | 378 | WP_000916345.1 | EthD family reductase | - |
| KFU99_RS22060 (4566382) | 4566382..4566714 | + | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| KFU99_RS22070 (4567158) | 4567158..4567733 | - | 576 | WP_001188509.1 | transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| flank | IS/Tn | - | - | 4559798..4560256 | 458 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17663.44 Da Isoelectric Point: 7.2655
>T201408 WP_000625911.1 NZ_CP074094:4563233-4563724 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T201408 NZ_CP098353:c6108-5803 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCTGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCTGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGACGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10938.54 Da Isoelectric Point: 9.8590
>AT201408 WP_001271379.1 NZ_CP074094:4562943-4563236 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT201408 NZ_CP098353:c6328-6110 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACTGTCACCATAGACAGTGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA
ATGAAGCAGCGCATCACTGTCACCATAGACAGTGACAGTTATCAGTTACTGAAATCCGCAGACGTCAATATCTCCGCCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTTCCGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G3E5T9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V7IUD2 |