Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4562576..4563357 | Replicon | chromosome |
| Accession | NZ_CP074092 | ||
| Organism | Salmonella enterica subsp. enterica serovar Typhimurium strain SO_8752_Stm | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | E8X9W8 |
| Locus tag | KFK83_RS22035 | Protein ID | WP_000626099.1 |
| Coordinates | 4562866..4563357 (+) | Length | 164 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | B5R979 |
| Locus tag | KFK83_RS22030 | Protein ID | WP_001110452.1 |
| Coordinates | 4562576..4562869 (+) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFK83_RS21995 (4558188) | 4558188..4559093 | + | 906 | WP_001268200.1 | YjiK family protein | - |
| KFK83_RS22000 (4559432) | 4559432..4559890 | + | 459 | WP_000502119.1 | IS200/IS605-like element IS200F family transposase | - |
| KFK83_RS22005 (4560099) | 4560099..4560368 | - | 270 | WP_010989096.1 | hypothetical protein | - |
| KFK83_RS22010 (4560376) | 4560376..4560591 | - | 216 | WP_001595136.1 | hypothetical protein | - |
| KFK83_RS22015 (4560614) | 4560614..4560901 | - | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| KFK83_RS22020 (4560898) | 4560898..4561773 | - | 876 | WP_000921675.1 | AraC family transcriptional regulator | - |
| KFK83_RS22025 (4562038) | 4562038..4562259 | - | 222 | WP_001576552.1 | hypothetical protein | - |
| KFK83_RS22030 (4562576) | 4562576..4562869 | + | 294 | WP_001110452.1 | DUF1778 domain-containing protein | Antitoxin |
| KFK83_RS22035 (4562866) | 4562866..4563357 | + | 492 | WP_000626099.1 | GNAT family N-acetyltransferase | Toxin |
| KFK83_RS22040 (4563605) | 4563605..4564357 | - | 753 | WP_000842434.1 | non-specific acid phosphatase | - |
| KFK83_RS22045 (4564460) | 4564460..4564534 | - | 75 | Protein_4313 | porin family protein | - |
| KFK83_RS22050 (4565566) | 4565566..4565943 | - | 378 | WP_000916345.1 | EthD family reductase | - |
| KFK83_RS22055 (4566015) | 4566015..4566347 | + | 333 | WP_001165471.1 | MerR family transcriptional regulator | - |
| KFK83_RS22060 (4566438) | 4566438..4566515 | + | 78 | Protein_4316 | helix-turn-helix domain-containing protein | - |
| KFK83_RS22070 (4566786) | 4566786..4567361 | - | 576 | WP_001188509.1 | transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| flank | IS/Tn | - | - | 4559432..4559890 | 458 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 164 a.a. Molecular weight: 17646.39 Da Isoelectric Point: 6.8437
>T201384 WP_000626099.1 NZ_CP074092:4562866-4563357 [Salmonella enterica subsp. enterica serovar Typhimurium]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV
Download Length: 492 bp
>T201384 NZ_CP098350:324617-324985 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCAGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACTCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCGGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCGGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGCTTGCGCGGATGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10977.61 Da Isoelectric Point: 8.6141
>AT201384 WP_001110452.1 NZ_CP074092:4562576-4562869 [Salmonella enterica subsp. enterica serovar Typhimurium]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK
Download Length: 294 bp
>AT201384 NZ_CP098350:324399-324620 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGACGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7AK7 | |
| AlphaFold DB | A0A5I1DGA4 |