Detailed information of TA system TA201383

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4241649..4242251
• Replicon: chromosome
• Accession: NZ_CP074092
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain SO_8752_Stm

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: KFK83_RS20605
• Protein ID: WP_001159630.1
• Coordinates: 4241649..4241960 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: KFK83_RS20610
• Protein ID: WP_000362050.1
• Coordinates: 4241961..4242251 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFK83_RS20570 (4236762)	4236762..4237361	+	600	WP_000965695.1	glucose-1-phosphatase	-
KFK83_RS20575 (4237355)	4237355..4238227	+	873	WP_000921427.1	virulence factor BrkB family protein	-
KFK83_RS20580 (4238224)	4238224..4238661	+	438	WP_000560974.1	D-aminoacyl-tRNA deacylase	-
KFK83_RS20585 (4238706)	4238706..4239647	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
KFK83_RS20590 (4239662)	4239662..4240108	-	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	-
KFK83_RS20595 (4240105)	4240105..4240416	-	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	-
KFK83_RS20600 (4240502)	4240502..4241431	-	930	WP_001127703.1	alpha/beta hydrolase	-
KFK83_RS20605 (4241649)	4241649..4241960	+	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
KFK83_RS20610 (4241961)	4241961..4242251	+	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
KFK83_RS20615 (4242298)	4242298..4243227	-	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
KFK83_RS20620 (4243224)	4243224..4243859	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
KFK83_RS20625 (4243856)	4243856..4244758	-	903	WP_000331361.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T201383 WP_001159630.1 NZ_CP074092:4241649-4241960 [Salmonella enterica subsp. enterica serovar Typhimurium]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T201383 NZ_CP098349:160519-160824 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT201383 WP_000362050.1 NZ_CP074092:4241961-4242251 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT201383 NZ_CP098349:160299-160517 [Klebsiella pneumoniae]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64