Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2552113..2552741 Replicon chromosome
Accession NZ_CP074073
Organism Idiomarina loihiensis strain SN11

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KF946_RS12220 Protein ID WP_153850219.1
Coordinates 2552448..2552741 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KF946_RS12215 Protein ID WP_153850220.1
Coordinates 2552113..2552436 (-) Length 108 a.a.

Genomic Context

KF946_RS12200KF946_RS12205KF946_RS12225KF946_RS12230KF946_RS12240KF946_RS12245KF946_RS12260KF946_RS12190KF946_RS12195KF946_RS12210KF946_RS12215KF946_RS12220KF946_RS12235KF946_RS12250KF946_RS12255
Location: 2549889..2550950 (1062 bp)
Type: Others
Protein ID: WP_228758016.1
Location: 2551044..2551337 (294 bp)
Type: Others
Protein ID: WP_034822886.1
Location: 2552944..2554224 (1281 bp)
Type: Others
Protein ID: WP_153850218.1
Location: 2554227..2554934 (708 bp)
Type: Others
Protein ID: WP_153850217.1
Location: 2555639..2555911 (273 bp)
Type: Others
Protein ID: WP_114982302.1
Location: 2555898..2556239 (342 bp)
Type: Others
Protein ID: WP_153850215.1
Location: 2557066..2557722 (657 bp)
Type: Others
Protein ID: WP_110013507.1
Location: 2547469..2549028 (1560 bp)
Type: Others
Protein ID: WP_153850223.1
Location: 2549136..2549645 (510 bp)
Type: Others
Protein ID: WP_153850222.1
Location: 2551339..2551986 (648 bp)
Type: Others
Protein ID: WP_153850221.1
Location: 2552113..2552436 (324 bp)
Type: Antitoxin
Protein ID: WP_153850220.1
Location: 2552448..2552741 (294 bp)
Type: Toxin
Protein ID: WP_153850219.1
Location: 2554931..2555536 (606 bp)
Type: Others
Protein ID: WP_153850216.1
Location: 2556263..2556712 (450 bp)
Type: Others
Protein ID: WP_153850214.1
Location: 2556709..2556939 (231 bp)
Type: Others
Protein ID: WP_153850213.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
KF946_RS12190 (KF946_12175)2547469..2549028-1560WP_153850223.1DNA (cytosine-5-)-methyltransferase-
KF946_RS12195 (KF946_12180)2549136..2549645-510WP_153850222.1very short patch repair endonuclease-
KF946_RS12200 (KF946_12185)2549889..2550950+1062WP_228758016.1alpha/beta hydrolase-fold protein-
KF946_RS12205 (KF946_12190)2551044..2551337+294WP_034822886.1type I toxin-antitoxin system antitoxin YafN-
KF946_RS12210 (KF946_12195)2551339..2551986-648WP_153850221.1hypothetical protein-
KF946_RS12215 (KF946_12200)2552113..2552436-324WP_153850220.1HigA family addiction module antitoxinAntitoxin
KF946_RS12220 (KF946_12205)2552448..2552741-294WP_153850219.1type II toxin-antitoxin system RelE/ParE family toxinToxin
KF946_RS12225 (KF946_12210)2552944..2554224+1281WP_153850218.1anti-phage deoxyguanosine triphosphatase-
KF946_RS12230 (KF946_12215)2554227..2554934+708WP_153850217.1ZIP family metal transporter-
KF946_RS12235 (KF946_12220)2554931..2555536-606WP_153850216.1hypothetical protein-
KF946_RS12240 (KF946_12225)2555639..2555911+273WP_114982302.1type II toxin-antitoxin system prevent-host-death family antitoxin-
KF946_RS12245 (KF946_12230)2555898..2556239+342WP_153850215.1type II toxin-antitoxin system RelE/ParE family toxin-
KF946_RS12250 (KF946_12235)2556263..2556712-450WP_153850214.1type II toxin-antitoxin system VapC family toxin-
KF946_RS12255 (KF946_12240)2556709..2556939-231WP_153850213.1type II toxin-antitoxin system VapB family antitoxin-
KF946_RS12260 (KF946_12245)2557066..2557722+657WP_110013507.1epoxyqueuosine reductase QueH-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-85)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11520.22 Da        Isoelectric Point: 7.8732

>T201333 WP_153850219.1 NZ_CP074073:c2552741-2552448 [Idiomarina loihiensis]
MAVKFRDDWLERFYEDDISHKKIPKIIKGALFRKLEILDAATQESDLRVPLGNRFEYLKGKLSGCCSIRVNRQYRLIFHW
EDGIAQDTYLDPHVYQS

Download         Length: 294 bp

>T201333 NZ_CP098338:2114974-2115076 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12351.37 Da        Isoelectric Point: 10.2550

>AT201333 WP_153850220.1 NZ_CP074073:c2552436-2552113 [Idiomarina loihiensis]
MRDTKRRPVSVGQMLITEFLEPMNIEIKELADAMRVHRNTLSRIVHDKGALTAPMAIKLAAALGNTPEFWLNIKHAVEIW
DVRHRAYEQEAENVKRLKPHAKPYQQA

Download         Length: 324 bp

>AT201333 NZ_CP098338:c2115083-2114938 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References