Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2552113..2552741 Replicon chromosome
Accession NZ_CP074073
Organism Idiomarina loihiensis strain SN11

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KF946_RS12220 Protein ID WP_153850219.1
Coordinates 2552448..2552741 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KF946_RS12215 Protein ID WP_153850220.1
Coordinates 2552113..2552436 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KF946_RS12190 (KF946_12175) 2547469..2549028 - 1560 WP_153850223.1 DNA (cytosine-5-)-methyltransferase -
KF946_RS12195 (KF946_12180) 2549136..2549645 - 510 WP_153850222.1 very short patch repair endonuclease -
KF946_RS12200 (KF946_12185) 2549889..2550950 + 1062 WP_228758016.1 alpha/beta hydrolase-fold protein -
KF946_RS12205 (KF946_12190) 2551044..2551337 + 294 WP_034822886.1 type I toxin-antitoxin system antitoxin YafN -
KF946_RS12210 (KF946_12195) 2551339..2551986 - 648 WP_153850221.1 hypothetical protein -
KF946_RS12215 (KF946_12200) 2552113..2552436 - 324 WP_153850220.1 HigA family addiction module antitoxin Antitoxin
KF946_RS12220 (KF946_12205) 2552448..2552741 - 294 WP_153850219.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KF946_RS12225 (KF946_12210) 2552944..2554224 + 1281 WP_153850218.1 anti-phage deoxyguanosine triphosphatase -
KF946_RS12230 (KF946_12215) 2554227..2554934 + 708 WP_153850217.1 ZIP family metal transporter -
KF946_RS12235 (KF946_12220) 2554931..2555536 - 606 WP_153850216.1 hypothetical protein -
KF946_RS12240 (KF946_12225) 2555639..2555911 + 273 WP_114982302.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
KF946_RS12245 (KF946_12230) 2555898..2556239 + 342 WP_153850215.1 type II toxin-antitoxin system RelE/ParE family toxin -
KF946_RS12250 (KF946_12235) 2556263..2556712 - 450 WP_153850214.1 type II toxin-antitoxin system VapC family toxin -
KF946_RS12255 (KF946_12240) 2556709..2556939 - 231 WP_153850213.1 type II toxin-antitoxin system VapB family antitoxin -
KF946_RS12260 (KF946_12245) 2557066..2557722 + 657 WP_110013507.1 epoxyqueuosine reductase QueH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(3-93)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-85)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11520.22 Da        Isoelectric Point: 7.8732

>T201333 WP_153850219.1 NZ_CP074073:c2552741-2552448 [Idiomarina loihiensis]
MAVKFRDDWLERFYEDDISHKKIPKIIKGALFRKLEILDAATQESDLRVPLGNRFEYLKGKLSGCCSIRVNRQYRLIFHW
EDGIAQDTYLDPHVYQS

Download         Length: 294 bp

>T201333 NZ_CP098338:2114974-2115076 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 12351.37 Da        Isoelectric Point: 10.2550

>AT201333 WP_153850220.1 NZ_CP074073:c2552436-2552113 [Idiomarina loihiensis]
MRDTKRRPVSVGQMLITEFLEPMNIEIKELADAMRVHRNTLSRIVHDKGALTAPMAIKLAAALGNTPEFWLNIKHAVEIW
DVRHRAYEQEAENVKRLKPHAKPYQQA

Download         Length: 324 bp

>AT201333 NZ_CP098338:c2115083-2114938 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References