Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
| Location | 3691114..3691808 | Replicon | chromosome |
| Accession | NZ_CP074047 | ||
| Organism | Escherichia coli strain PD7 | ||
Toxin (Protein)
| Gene name | yafO | Uniprot ID | S1EXB8 |
| Locus tag | KFU78_RS17975 | Protein ID | WP_001263493.1 |
| Coordinates | 3691114..3691512 (-) | Length | 133 a.a. |
Antitoxin (Protein)
| Gene name | yafN | Uniprot ID | S1FJN6 |
| Locus tag | KFU78_RS17980 | Protein ID | WP_000554757.1 |
| Coordinates | 3691515..3691808 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| - (3686774) | 3686774..3686854 | - | 81 | NuclAT_12 | - | - |
| - (3686774) | 3686774..3686854 | - | 81 | NuclAT_12 | - | - |
| - (3686774) | 3686774..3686854 | - | 81 | NuclAT_12 | - | - |
| - (3686774) | 3686774..3686854 | - | 81 | NuclAT_12 | - | - |
| KFU78_RS17945 (3686114) | 3686114..3687358 | - | 1245 | WP_000189541.1 | esterase FrsA | - |
| KFU78_RS17950 (3687450) | 3687450..3687908 | - | 459 | WP_001291990.1 | xanthine phosphoribosyltransferase | - |
| KFU78_RS17955 (3688169) | 3688169..3689626 | + | 1458 | WP_001293003.1 | cytosol nonspecific dipeptidase | - |
| KFU78_RS17960 (3689683) | 3689683..3690204 | - | 522 | Protein_3513 | peptide chain release factor H | - |
| KFU78_RS17965 (3690203) | 3690203..3690406 | - | 204 | Protein_3514 | RtcB family protein | - |
| KFU78_RS17970 (3690652) | 3690652..3691104 | - | 453 | WP_001059847.1 | GNAT family N-acetyltransferase | - |
| KFU78_RS17975 (3691114) | 3691114..3691512 | - | 399 | WP_001263493.1 | type II toxin-antitoxin system mRNA interferase toxin YafO | Toxin |
| KFU78_RS17980 (3691515) | 3691515..3691808 | - | 294 | WP_000554757.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
| KFU78_RS17985 (3691860) | 3691860..3692915 | - | 1056 | WP_001226164.1 | DNA polymerase IV | - |
| KFU78_RS17990 (3692986) | 3692986..3693771 | - | 786 | WP_000207564.1 | putative lateral flagellar export/assembly protein LafU | - |
| KFU78_RS17995 (3693743) | 3693743..3695455 | + | 1713 | Protein_3520 | flagellar biosynthesis protein FlhA | - |
| KFU78_RS18000 (3695679) | 3695679..3696176 | - | 498 | WP_000006255.1 | REP-associated tyrosine transposase RayT | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | gmhA/lpcA / hcp1/tssD1 | 3552689..3724152 | 171463 | |
| - | inside | Prophage | - | gmhA/lpcA / hcp1/tssD1 | 3617651..3724152 | 106501 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15472.83 Da Isoelectric Point: 8.0949
>T201302 WP_001263493.1 NZ_CP074047:c3691512-3691114 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
Download Length: 399 bp
>T201302 NZ_CP098329:c8302-7958 [Lactiplantibacillus plantarum]
ATGGTAAACCAAGGTGATATATTTTATGTTAACTTTAATCCAAGCCGTGGTCATGAACAGATGAATAAGCGACCAGCCAT
TGCTCTAAGCAATGATCTAGTCTGTCAGACAAGTAACATGACGATTGTGGCTCCAATTAGCAGTACCAAGCGTAATTTTC
CAATGTATCATCGACTAACTAGTAGTCAAACGGTATATGGAAAAGTATTATTAGATCAAACCATAGCCTTAGATTTACGG
GCAAGACATGTCACTGATGAAACTATTGTCGATCATGTATCGCGTGAAGAACTAGAAGAAATAATCACTTTGTACAAATT
ATTGTTTAGTATTGATGACAAATAG
ATGGTAAACCAAGGTGATATATTTTATGTTAACTTTAATCCAAGCCGTGGTCATGAACAGATGAATAAGCGACCAGCCAT
TGCTCTAAGCAATGATCTAGTCTGTCAGACAAGTAACATGACGATTGTGGCTCCAATTAGCAGTACCAAGCGTAATTTTC
CAATGTATCATCGACTAACTAGTAGTCAAACGGTATATGGAAAAGTATTATTAGATCAAACCATAGCCTTAGATTTACGG
GCAAGACATGTCACTGATGAAACTATTGTCGATCATGTATCGCGTGAAGAACTAGAAGAAATAATCACTTTGTACAAATT
ATTGTTTAGTATTGATGACAAATAG
Antitoxin
Download Length: 98 a.a. Molecular weight: 11233.81 Da Isoelectric Point: 5.9050
>AT201302 WP_000554757.1 NZ_CP074047:c3691808-3691515 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
Download Length: 294 bp
>AT201302 NZ_CP098329:c8559-8296 [Lactiplantibacillus plantarum]
ATGGAACTTATTAAAGAACAAACACGCTTAGCAAAGTGGGGAAACTCGAAAGCTGCTAGAATTCCTAGCCAAATTATTAA
ACAACTGAAATTAGATGATAACCAAGATATGACAATAACCATTGAAAATGGATCAATTGTTTTAACACCAATAAAAAAGA
ACCCAACCAATATTCACGAACTATTTAAGGATTGGAAAGATGACGGGAAAAGGGATCACGAGCTTGATTGGGGAAAGTCA
GAAGGTAATGAACTTCAATGGTAA
ATGGAACTTATTAAAGAACAAACACGCTTAGCAAAGTGGGGAAACTCGAAAGCTGCTAGAATTCCTAGCCAAATTATTAA
ACAACTGAAATTAGATGATAACCAAGATATGACAATAACCATTGAAAATGGATCAATTGTTTTAACACCAATAAAAAAGA
ACCCAACCAATATTCACGAACTATTTAAGGATTGGAAAGATGACGGGAAAAGGGATCACGAGCTTGATTGGGGAAAGTCA
GAAGGTAATGAACTTCAATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|