Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1764467..1764969 Replicon chromosome
Accession NZ_CP074047
Organism Escherichia coli strain PD7

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag KFU78_RS08335 Protein ID WP_000767829.1
Coordinates 1764715..1764969 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag KFU78_RS08330 Protein ID WP_001259255.1
Coordinates 1764467..1764718 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU78_RS08305 (1759644) 1759644..1760711 - 1068 WP_000080081.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
KFU78_RS08310 (1760711) 1760711..1761781 - 1071 WP_032250198.1 histidinol-phosphate transaminase -
KFU78_RS08315 (1761778) 1761778..1763082 - 1305 WP_032253986.1 histidinol dehydrogenase -
KFU78_RS08320 (1763088) 1763088..1763987 - 900 WP_032250195.1 ATP phosphoribosyltransferase -
KFU78_RS08325 (1764133) 1764133..1764183 - 51 WP_001364200.1 his operon leader peptide -
KFU78_RS08330 (1764467) 1764467..1764718 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
KFU78_RS08335 (1764715) 1764715..1764969 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
KFU78_RS08340 (1765052) 1765052..1765876 + 825 WP_000754734.1 SDR family oxidoreductase -
KFU78_RS08345 (1765922) 1765922..1766851 + 930 WP_032250194.1 LysR substrate-binding domain-containing protein -
KFU78_RS08350 (1767066) 1767066..1767128 + 63 WP_010723108.1 membrane protein YoeI -
KFU78_RS08355 (1767118) 1767118..1768476 + 1359 WP_063101502.1 putrescine/proton symporter PlaP -
KFU78_RS08360 (1768655) 1768655..1769713 + 1059 WP_000492305.1 thiosulfate utilization transporter TsuA/YeeE -
KFU78_RS08365 (1769727) 1769727..1769954 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T201288 WP_000767829.1 NZ_CP074047:1764715-1764969 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T201288 NZ_CP098322:2815096-2816061 [Burkholderia gladioli]
ATGAGCGAAATCGATCCGCGCGGGGCCGAGGCAGAGGCCGGGCCCGACGCGGCCCTGGCCGCCCGACTCGGGCAGTTCCC
GGCGCGGCGCATCGCCATTCGCGAAGCCGGGCTGATCGGCTGGCGCGAATCGGGTCCAGTTGAGGGGGCCGGCGATTCGA
CGGCACGCGCGGCCGCTGGCGAGCGGGCATTGCCGGTGGTGCTGCTGCACGGCATCGGCTCGGGCGCGGCCTCGTGGCTG
GCCCAGCTCGACACGCTCGGCGCGTCGCGTCGCGTGCTGGCCTGGGACGCGCCCGGTTATGGCGAATCGACGCCGGTCGC
GCCGGCCTCGCCGCTGGCGGCCGATTACGCGGCGTCGCTGGCCGGCTGGCTCGACGCGCTCGCCATCGAGCGCTGCGTGC
TGGTGGGGCACTCGCTCGGCGCGATCGTGGCCGGCGCCTTCGCGCGCCGGCATGCCGGGCGGCTGGCCGGCTTGCTGCTG
GTTTCGCCGGCCGCCGGCTACGGCGCGGCGCCGGCCGCCACGCGCGACGAACGGCGCGATGCGCGGCTCGCGATGCTGGC
CGCGCTCGGGCCCGCGGGCCTGGCCGAACAACGCAGCGCCAACATGCTGTCGGCGCATGCCGGCGAGGCCGCCCGCGCCT
GGGTGCGCCGCGTGATGGCGCAGGTGAAGCCGGCCGGCTACACGCAGGCCACCCACCTGCTCGCGAACGCCGACCTGGCC
GCCGATCTCGCCGCCTGGCGGGCGATGACCGACGCCGCCGGTGCCGCGCGCGTGGAGGTGATGGTGGGCGCCGAGGACGG
CATCACGCCGCCGAATGCCTGCGAACGGCTCGCGGCGGCGGCCGGCGTGGCGCTGCGCATCGTGCCGCGCGCCGGCCATG
CCGGCTACGTGGAGGCACCCGAGCGCTACTCGGCGCTGATCGGCGCGTTCTGCGCGCGCTGCGACGAATCATGGAGACAG
GCATGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT201288 WP_001259255.1 NZ_CP074047:1764467-1764718 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT201288 NZ_CP098322:2816058-2816939 [Burkholderia gladioli]
ATGAACCCGACCCAACTCGCCCTGCGAAGCGAGCCGGCCGACAGCGGCGCGCCCGAGGCGGATGCCGCGAACGGCGCCTA
CGTGGTACCTGGCCTCGAACGCGGGCTGCGGATCCTCGCGGAATTCTCGCCGCGCGAGCCGGTGCTGGGCGCGCCGGAAT
TGTCGAAGCGGCTCGGCATTCCACGCACCACGGTGTTCCGGCTGCTGCAGACGCTCGAATCGCTGGGCTTCCTGGAGCGC
GCCGACAAGGACCGCAATTACCGGCTCGGCGTGGCGGTGCTGCGCCTGGGCTTCGAATACTTGAGCTCGCTGGAGCTGAC
CGACCTGGGCCTGCCAGTGATCGAGGGCCTGCGCGAGGCGACCGGCTTCACCACCCATATCGTGATCCGCGACGGCCGCG
ACGTGGTGTTCGTCGCCAAGGCGCAGAGCGCGGCGCCGGCCTTCAGCTCGATTCGCGTCAACGTCGGCACGCGGCTGCCC
GCGCATGCCACCACCCACGGCCACGTGCTGATGGGCGACCTGAGCGAGGCCGAGCTGCGCGCGCTGTACCCCGAGCGCCA
GCTCGAACGCGCCACGCGCGCCACGCCCGACAGCCTGGAGGCGCTGCTCGCGCTGGTCCGCGAGGATGCCGCGCGCGGCT
ACGGCATCAGCAACTCCTCGTTCGAGCGCGGCATCTCGGTGGTCACCGCGCCGGTGCGCAACGACACGCAGCGCATCGTG
GCGGCCGTCACGGTGACGGTGCCGAAACCCGAGATCGACGCGGCGCTGATCGCCGACGGCCTGGTCGAGAAGGTCGTGAG
GGCGGCCAATGAACTGTCGCGGCGGCTCAATTACCGCTCCGATGATGAGAACTCCTATCTGAAGGCATTGGGATTGCGAT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References