Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 644798..645525 | Replicon | chromosome |
| Accession | NZ_CP074047 | ||
| Organism | Escherichia coli strain PD7 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | U9ZMR4 |
| Locus tag | KFU78_RS03200 | Protein ID | WP_000550189.1 |
| Coordinates | 644798..645112 (+) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | KFU78_RS03205 | Protein ID | WP_000560266.1 |
| Coordinates | 645109..645525 (+) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFU78_RS03180 (640956) | 640956..641942 | - | 987 | WP_000617698.1 | Gfo/Idh/MocA family oxidoreductase | - |
| KFU78_RS03185 (642021) | 642021..642713 | - | 693 | WP_222898825.1 | vancomycin high temperature exclusion protein | - |
| KFU78_RS03190 (642790) | 642790..643293 | - | 504 | WP_001333820.1 | M48 family metallopeptidase | - |
| KFU78_RS03195 (643378) | 643378..644514 | + | 1137 | WP_000018695.1 | 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG | - |
| KFU78_RS03200 (644798) | 644798..645112 | + | 315 | WP_000550189.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| KFU78_RS03205 (645109) | 645109..645525 | + | 417 | WP_000560266.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| KFU78_RS03210 (645570) | 645570..647588 | - | 2019 | WP_000121433.1 | NADPH-dependent 2,4-dienoyl-CoA reductase | - |
| KFU78_RS03215 (648014) | 648014..650365 | - | 2352 | WP_222898826.1 | alpha-glucosidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 12103.10 Da Isoelectric Point: 10.0409
>T201284 WP_000550189.1 NZ_CP074047:644798-645112 [Escherichia coli]
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
MHLITQKALKDAAEKYPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
Download Length: 315 bp
>T201284 NZ_CP098321:c3105481-3104897 [Burkholderia gladioli]
ATGGACGACGCGTTGATCGACGCACGACTGGATTTCCTGCGCGGCTGCGAGCGCCTGAAGGATGTGCTGCGCAGCGGCCA
TACCTCGGGCGGGCGACGCGAGAGCACGGCCGAGCACAGCTGGCGGCTCGCGCTGATGGCGATGGTGCTGATGGATCAAT
TGGGCGAGGTCGACCCCGGCAGGGTGCTCGAGCTCTGCCTGGTGCATGACCTGGGCGAAGCGCTGGGCGGCGACGTGCCG
GCGCCCGAGCAGGCCCCGGGCAGCGACAAGGATGCCGCCGAGCGACGCGACCTGCTGCGCCTCGGCGACGCGCTCGATGC
GCCGATGCGCGAGAGGATCGTCGCGTTGTGGGACGAGTATGCGCGGGCGGCCACGCCGGAAGCACGCGCGGTGAAGGCGC
TCGACAAGATCGAGACGATCCTGCAGCACACGCAGGGCGAGAATCCGCCCGATTTCGACTATGCGTTCAATCTCGCGTAT
GGACAGGCGCATACCCGCAAGGTGCCGGCGCTGCAGCGGTTTCGCGAGCGCCTCGACGAGGCGACGCGCGAGCGGATGGC
CCGTGCTGGCGGGCCTTCGGGCTGA
ATGGACGACGCGTTGATCGACGCACGACTGGATTTCCTGCGCGGCTGCGAGCGCCTGAAGGATGTGCTGCGCAGCGGCCA
TACCTCGGGCGGGCGACGCGAGAGCACGGCCGAGCACAGCTGGCGGCTCGCGCTGATGGCGATGGTGCTGATGGATCAAT
TGGGCGAGGTCGACCCCGGCAGGGTGCTCGAGCTCTGCCTGGTGCATGACCTGGGCGAAGCGCTGGGCGGCGACGTGCCG
GCGCCCGAGCAGGCCCCGGGCAGCGACAAGGATGCCGCCGAGCGACGCGACCTGCTGCGCCTCGGCGACGCGCTCGATGC
GCCGATGCGCGAGAGGATCGTCGCGTTGTGGGACGAGTATGCGCGGGCGGCCACGCCGGAAGCACGCGCGGTGAAGGCGC
TCGACAAGATCGAGACGATCCTGCAGCACACGCAGGGCGAGAATCCGCCCGATTTCGACTATGCGTTCAATCTCGCGTAT
GGACAGGCGCATACCCGCAAGGTGCCGGCGCTGCAGCGGTTTCGCGAGCGCCTCGACGAGGCGACGCGCGAGCGGATGGC
CCGTGCTGGCGGGCCTTCGGGCTGA
Antitoxin
Download Length: 139 a.a. Molecular weight: 14995.42 Da Isoelectric Point: 4.4547
>AT201284 WP_000560266.1 NZ_CP074047:645109-645525 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
Download Length: 417 bp
>AT201284 NZ_CP098321:c3106174-3105584 [Burkholderia gladioli]
ATGAAACCGATATCGTCGAACCAGGCAACGACCACGTCCTTGCCGCCGTCCGCGCTGGCCTGTTCGCCGGGCGCGAGCTT
GCGTCGATGGCGCACGCTGCGCCGGATCAAGCAGGAACATGCAGCGGCGCTGTTCGGCGTATCGCAGTCGACGATATCGC
GCTGGGAAGCCGGCACGCAGGCGGTGTCGCACGAGGAACTGCGGCGCATCGAGGCCTGCTTGTCGGCGCGCCTCGACTCG
GCGGCGGATCGCGCGCTCGAGCGCCTCGTCAGCCATCACACCCGTCCCGTTCATCTCGTCTGCGACCTCACGCACCGGCT
GCTGGCCTGCTCCGCGCCGCGAGCCGCGGAGTTCGCGGCGCCGCTGTCGTCGCTGATGGGCGCGTCGCTCTGGCCGTTCG
CGACGGCCGAGATCGTGGCGCGCGAGCAGTCGTTGCGCGATGCGGGCTGGCAAGATCATCCGGCACCCTCGATCGAATTC
GATACCGGGTCCAACGATTCGCCTCAGGTGCCGATTCGTGCGAGCCGCTGCCGCTGGACGCGTTTCACCTTGTCCGACGG
GACGCTGGCGCGCCTGGTCGAGACGCTTTGA
ATGAAACCGATATCGTCGAACCAGGCAACGACCACGTCCTTGCCGCCGTCCGCGCTGGCCTGTTCGCCGGGCGCGAGCTT
GCGTCGATGGCGCACGCTGCGCCGGATCAAGCAGGAACATGCAGCGGCGCTGTTCGGCGTATCGCAGTCGACGATATCGC
GCTGGGAAGCCGGCACGCAGGCGGTGTCGCACGAGGAACTGCGGCGCATCGAGGCCTGCTTGTCGGCGCGCCTCGACTCG
GCGGCGGATCGCGCGCTCGAGCGCCTCGTCAGCCATCACACCCGTCCCGTTCATCTCGTCTGCGACCTCACGCACCGGCT
GCTGGCCTGCTCCGCGCCGCGAGCCGCGGAGTTCGCGGCGCCGCTGTCGTCGCTGATGGGCGCGTCGCTCTGGCCGTTCG
CGACGGCCGAGATCGTGGCGCGCGAGCAGTCGTTGCGCGATGCGGGCTGGCAAGATCATCCGGCACCCTCGATCGAATTC
GATACCGGGTCCAACGATTCGCCTCAGGTGCCGATTCGTGCGAGCCGCTGCCGCTGGACGCGTTTCACCTTGTCCGACGG
GACGCTGGCGCGCCTGGTCGAGACGCTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|