Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 103584..104010 | Replicon | plasmid pYLPK12 |
| Accession | NZ_CP074032 | ||
| Organism | Escherichia coli strain PK12 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | KFU67_RS24920 | Protein ID | WP_001372321.1 |
| Coordinates | 103584..103709 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 103786..104010 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFU67_RS24880 (98956) | 98956..99645 | - | 690 | WP_000283385.1 | conjugal transfer transcriptional regulator TraJ | - |
| KFU67_RS24885 (99832) | 99832..100215 | - | 384 | WP_001151524.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| KFU67_RS24890 (100536) | 100536..101138 | + | 603 | WP_072156291.1 | transglycosylase SLT domain-containing protein | - |
| KFU67_RS24895 (101435) | 101435..102256 | - | 822 | WP_001234469.1 | DUF932 domain-containing protein | - |
| KFU67_RS24900 (102375) | 102375..102662 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| KFU67_RS24905 (102687) | 102687..102893 | - | 207 | WP_000547971.1 | hypothetical protein | - |
| KFU67_RS24910 (102963) | 102963..103136 | + | 174 | Protein_122 | hypothetical protein | - |
| KFU67_RS24915 (103134) | 103134..103364 | - | 231 | WP_001426396.1 | hypothetical protein | - |
| KFU67_RS24920 (103584) | 103584..103709 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| KFU67_RS24925 (103651) | 103651..103800 | - | 150 | Protein_125 | plasmid maintenance protein Mok | - |
| - (103786) | 103786..104010 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (103786) | 103786..104010 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (103786) | 103786..104010 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (103786) | 103786..104010 | - | 225 | NuclAT_0 | - | Antitoxin |
| KFU67_RS24930 (103822) | 103822..104010 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| KFU67_RS24935 (103979) | 103979..104741 | - | 763 | Protein_127 | plasmid SOS inhibition protein A | - |
| KFU67_RS24940 (104738) | 104738..105172 | - | 435 | WP_064770609.1 | conjugation system SOS inhibitor PsiB | - |
| KFU67_RS24945 (105227) | 105227..105424 | - | 198 | Protein_129 | hypothetical protein | - |
| KFU67_RS24950 (105452) | 105452..105685 | - | 234 | WP_000005987.1 | DUF905 family protein | - |
| KFU67_RS24955 (105753) | 105753..106292 | - | 540 | WP_000290840.1 | single-stranded DNA-binding protein | - |
| KFU67_RS24960 (106318) | 106318..106524 | - | 207 | WP_000275856.1 | hypothetical protein | - |
| KFU67_RS24965 (106594) | 106594..106674 | + | 81 | Protein_133 | hypothetical protein | - |
| KFU67_RS24970 (106857) | 106857..107026 | - | 170 | Protein_134 | hypothetical protein | - |
| KFU67_RS24975 (107663) | 107663..108634 | - | 972 | WP_000817028.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCTX-M-55 / tet(A) / aph(3')-Ia / catA2 / dfrA14 / sul2 / aph(3'')-Ib / aph(6)-Id / blaTEM-1B / sitABCD | iutA / iucD / iucC / iucB / iucA | 1..129015 | 129015 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T201220 WP_001372321.1 NZ_CP074032:c103709-103584 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T201220 NZ_CP098234:c654654-654190 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
Antitoxin
Download Length: 225 bp
>AT201220 NZ_CP074032:c104010-103786 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
