Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 808290..808983 Replicon chromosome
Accession NZ_CP074031
Organism Escherichia coli strain PK12

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KFU67_RS03955 Protein ID WP_000415584.1
Coordinates 808290..808586 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KFU67_RS03960 Protein ID WP_000650107.1
Coordinates 808588..808983 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU67_RS03920 (803378) 803378..803692 - 315 WP_000958598.1 putative quinol monooxygenase -
KFU67_RS03925 (803723) 803723..804304 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KFU67_RS03930 (804623) 804623..804955 + 333 WP_023149630.1 DUF2645 family protein -
KFU67_RS03935 (805001) 805001..806350 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KFU67_RS03940 (806347) 806347..807006 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KFU67_RS03945 (807158) 807158..807550 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KFU67_RS03950 (807603) 807603..808085 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KFU67_RS03955 (808290) 808290..808586 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KFU67_RS03960 (808588) 808588..808983 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KFU67_RS03965 (809116) 809116..810723 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KFU67_RS03970 (810861) 810861..813119 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T201191 WP_000415584.1 NZ_CP074031:808290-808586 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T201191 NZ_CP098229:c4644798-4644487 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTATTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT201191 WP_000650107.1 NZ_CP074031:808588-808983 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT201191 NZ_CP098229:c4644486-4644196 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References