Detailed information of TA system TA201183

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): timP-timR/-
• Location: 4268952..4269236
• Replicon: chromosome
• Accession: NZ_CP074028
• Organism: Escherichia coli strain PK13

Toxin (Protein)

• Gene name: timP
• Uniprot ID: -
• Locus tag: KFU76_RS20665
• Protein ID: WP_001385884.1
• Coordinates: 4268952..4269077 (-)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	timR
Locus tag	-
Coordinates	4269173..4269236 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFU76_RS20640	4264142..4265992	+	1851	WP_001196613.1	Fe-S protein assembly chaperone HscA	-
KFU76_RS20645	4265994..4266329	+	336	WP_001124469.1	ISC system 2Fe-2S type ferredoxin	-
KFU76_RS20650	4266341..4266541	+	201	WP_000523616.1	Fe-S cluster assembly protein IscX	-
KFU76_RS20655	4266719..4268002	+	1284	WP_000133582.1	aminopeptidase PepB	-
KFU76_RS20660	4268144..4268920	+	777	WP_001297328.1	enhanced serine sensitivity protein SseB	-
KFU76_RS20665	4268952..4269077	-	126	WP_001385884.1	small toxic inner membrane protein TimP	Toxin
KFU76_RS20670	4269088..4269210	+	123	WP_256385323.1	hypothetical protein	-
-	4269173..4269236	+	64	-	-	Antitoxin
KFU76_RS20675	4269253..4270098	-	846	WP_000108626.1	3-mercaptopyruvate sulfurtransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4496.28 Da
• Isoelectric Point: 9.6571

>T201183 WP_001385884.1 NZ_CP074028:c4269077-4268952 [Escherichia coli]
MKIRCFCIVLIVSGALFSQVNNNRSLSGDNLLVVNNLQSSK

Nucleotide

• Length: 126 bp

>T201183 NZ_CP098229:2830070-2830177 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 64 bp

>AT201183 NZ_CP074028:4269173-4269236 [Escherichia coli]
CAACCTGCTGGAAAGGCCGCGAACCAGACCAGCAATAAAAAACCGCCAAATTCGGCGGTTTTTT

Structures

Antitoxin