Detailed information of TA system TA020117

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): HipBST/-
• Location: 710645..711993
• Replicon: chromosome
• Accession: NC_000907
• Organism: Haemophilus influenzae Rd KW20

Toxin (Protein)

• Gene name: HipT
• Uniprot ID: -
• Locus tag: HI_RS03545
• Protein ID: WP_005694624.1
• Coordinates: 710645..711676 (-)
• Length: 344 a.a.

Antitoxin (Protein)

• Gene name: HipS
• Uniprot ID: A0A2S9RZQ1
• Locus tag: HI_RS03550
• Protein ID: WP_005672747.1
• Coordinates: 711673..711993 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HI_RS03535 (HI0663m)	707165..708910	+	1746	WP_005694625.1	ABC transporter ATP-binding protein/permease	-
HI_RS03540 (HI0664)	708903..710561	+	1659	WP_005667625.1	thiol reductant ABC exporter subunit CydC	-
HI_RS03545 (HI0665)	710645..711676	-	1032	WP_005694624.1	type II toxin-antitoxin system HipA family toxin	Toxin
HI_RS03550 (HI0666)	711673..711993	-	321	WP_005672747.1	HipA N-terminal domain-containing protein	Antitoxin
HI_RS03555 (HI0666.1)	711981..712289	-	309	WP_010869030.1	helix-turn-helix transcriptional regulator	-
HI_RS03560 (HI0667)	712489..713490	-	1002	WP_005694623.1	class II fructose-bisphosphatase	-
HI_RS03565 (HI0668)	713652..713870	+	219	WP_005650820.1	cell division protein ZapB	-
HI_RS03570 (HI0669)	713967..714407	+	441	WP_005694621.1	FMN-binding protein MioC	-
HI_RS03575 (HI0670)	714404..714838	+	435	WP_005694618.1	D-aminoacyl-tRNA deacylase	-
HI_RS03580 (HI0671)	715140..715616	-	477	WP_005687916.1	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-
HI_RS03585 (HI0672)	715613..716290	-	678	WP_005655267.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
HI_RS03590 (HI0673)	716290..716568	-	279	WP_005661211.1	cell division protein FtsB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (56-290)

Antitoxin

• HipA, N-terminal subdomain 1 (9-101)

Sequences

Toxin

Protein

• Length: 344 a.a.
• Molecular weight: 39832.46 Da
• Isoelectric Point: 6.4335

>T20117 WP_005694624.1 NC_000907:c711676-710645 [Haemophilus influenzae Rd KW20]
MNFCRILLKPLKKNEALSGYSAEGLHYLTDNKHFNPELPFSRQEFITVKPQKQQGMSISGFQPKLQLIIKDEHFDSVNQQ
GNYILKPSPEEYPFLAENEHATMRIMKELGFDVPENGLVSFAGEQNHKEFAFVITRFDRDKQQKPMHQEQLDGAMNIRDK
YGKIGADNEQYVSYEQIAKFILQHTENHLAQQREIFRRIIYAYLLGNNDLHLRNFSFIYPKNSHPKLAPIYDFVSVSPYP
EIFNSTLLALPLLAREEGNATLAKGFNTQYGEYIGDDFVEFGENIGLNKNVIIQKLIPEIIQEKEKVEQIYSQSFMPQPH
IDCVLKTYRKRLALLNLLNEPEL

Nucleotide

• Length: 1032 bp

>T20117 NC_000907:c711676-710645 [Haemophilus influenzae Rd KW20]
ATGAATTTTTGTCGTATTTTATTAAAGCCATTGAAGAAAAATGAAGCACTTTCAGGTTACAGTGCTGAAGGTTTGCATTA
CCTTACAGACAATAAACATTTTAATCCTGAATTACCCTTTTCTCGCCAAGAATTTATTACAGTGAAACCCCAAAAACAGC
AAGGAATGAGCATTTCAGGTTTTCAACCAAAATTACAGCTTATTATCAAAGATGAGCACTTTGACAGCGTAAATCAACAG
GGAAATTATATTTTAAAGCCCTCTCCAGAAGAGTATCCTTTTTTAGCTGAAAATGAACACGCCACCATGCGCATTATGAA
AGAATTAGGGTTTGATGTGCCAGAAAATGGTTTAGTTTCTTTTGCTGGCGAACAAAATCATAAAGAATTTGCTTTTGTTA
TAACGCGTTTTGATCGTGATAAACAGCAAAAACCAATGCACCAAGAACAACTTGATGGTGCAATGAATATTCGAGACAAG
TATGGAAAAATAGGTGCAGATAATGAGCAATATGTAAGTTATGAACAAATTGCTAAGTTTATTTTGCAGCACACAGAAAA
TCATTTAGCTCAGCAACGAGAAATTTTTCGTCGAATTATTTACGCTTATTTATTAGGAAATAATGATCTTCACTTACGCA
ATTTTTCATTTATTTATCCCAAAAACAGTCATCCAAAACTTGCTCCAATTTATGATTTTGTGTCAGTGTCGCCCTATCCT
GAAATATTTAATTCAACACTACTTGCTTTGCCATTGTTAGCGCGAGAAGAAGGTAATGCCACACTAGCCAAAGGATTTAA
TACTCAATACGGTGAATATATCGGCGATGATTTTGTCGAGTTTGGGGAAAATATTGGATTAAATAAAAATGTGATTATTC
AAAAATTAATTCCTGAAATTATACAAGAAAAGGAAAAAGTAGAGCAGATTTATTCACAATCCTTTATGCCGCAGCCACAT
ATTGATTGCGTGCTGAAAACTTATCGCAAGCGTTTAGCTTTGCTTAACCTATTAAATGAACCTGAACTATAA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12453.12 Da
• Isoelectric Point: 5.9670

>AT20117 WP_005672747.1 NC_000907:c711993-711673 [Haemophilus influenzae Rd KW20]
MRDLVRSGKVFLYGEFIGLLREDHRGFHFSYNPDYQGIPLSLSFPIEQSPFHSDTLFPYFASLVPEGWLKHKYALHQRID
ESDMFRFLLNNGENMLGAVQIQEEKQ

Nucleotide

• Length: 321 bp

>AT20117 NC_000907:c711993-711673 [Haemophilus influenzae Rd KW20]
ATGCGCGATTTAGTCCGCTCGGGAAAAGTATTTCTCTACGGCGAATTTATTGGCTTACTTAGAGAAGATCATCGTGGTTT
TCATTTTTCTTACAACCCCGATTATCAAGGAATACCGCTCTCTCTCAGCTTTCCTATTGAGCAAAGTCCTTTTCATTCTG
ACACCTTATTCCCTTATTTTGCATCGCTCGTCCCAGAAGGCTGGCTAAAACACAAATATGCACTTCATCAACGAATTGAT
GAAAGCGATATGTTTCGCTTTTTACTTAATAACGGGGAAAATATGTTAGGCGCAGTGCAAATTCAGGAAGAAAAACAATG
A

Structures

Antitoxin

• AlphaFold DB: A0A2S9RZQ1