Detailed information of TA system TA201156

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): symE-rdlD/SymE(toxin)
• Location: 3989827..3990239
• Replicon: chromosome
• Accession: NZ_CP074024
• Organism: Escherichia coli strain PK5

Toxin (Protein)

• Gene name: symE
• Uniprot ID: -
• Locus tag: KFU66_RS19240
• Protein ID: WP_097749251.1
• Coordinates: 3989898..3990239 (+)
• Length: 114 a.a.

Antitoxin (RNA)

Gene name	rdlD
Locus tag	-
Coordinates	3989827..3989903 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFU66_RS19230 (3986777)	3986777..3988366	+	1590	WP_097749252.1	type I restriction-modification system methyltransferase	-
KFU66_RS19235 (3988363)	3988363..3989670	+	1308	WP_219371218.1	restriction endonuclease subunit S	-
- (3989827)	3989827..3989903	-	77	NuclAT_14	-	Antitoxin
- (3989827)	3989827..3989903	-	77	NuclAT_14	-	Antitoxin
- (3989827)	3989827..3989903	-	77	NuclAT_14	-	Antitoxin
- (3989827)	3989827..3989903	-	77	NuclAT_14	-	Antitoxin
- (3989827)	3989827..3989903	-	77	NuclAT_15	-	Antitoxin
- (3989827)	3989827..3989903	-	77	NuclAT_15	-	Antitoxin
- (3989827)	3989827..3989903	-	77	NuclAT_15	-	Antitoxin
- (3989827)	3989827..3989903	-	77	NuclAT_15	-	Antitoxin
KFU66_RS19240 (3989898)	3989898..3990239	+	342	WP_097749251.1	endoribonuclease SymE	Toxin
KFU66_RS19245 (3990401)	3990401..3991165	+	765	Protein_3762	DUF3578 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (20-71)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12321.20 Da
• Isoelectric Point: 8.5012

>T201156 WP_097749251.1 NZ_CP074024:3989898-3990239 [Escherichia coli]
MTDTHFIAQPFEAEVSPANNRQLTVSYASRYPDYSRIPAITLKGQWLEAAGFATGTAVAVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQEFIGVIAGKHKVA

Nucleotide

• Length: 342 bp

>T201156 NZ_CP098227:c2449812-2449636 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCTTGTGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Nucleotide

• Length: 77 bp

>AT201156 NZ_CP074024:c3989903-3989827 [Escherichia coli]
AGTCATAACTGCTATTCTCCTGGAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin