Detailed information of TA system TA201104

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 600562..600820
• Replicon: chromosome
• Accession: NZ_CP074019
• Organism: Escherichia coli strain PM22

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: KFU87_RS02870
• Protein ID: WP_000809168.1
• Coordinates: 600562..600714 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	600763..600820 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFU87_RS02850	595803..596516	-	714	WP_001102379.1	acidic protein MsyB	-
KFU87_RS02855	596542..596946	-	405	WP_000843559.1	DUF2541 family protein	-
KFU87_RS02860	597323..599239	+	1917	WP_000516135.1	molecular chaperone DnaK	-
KFU87_RS02865	599328..600458	+	1131	WP_001118464.1	molecular chaperone DnaJ	-
KFU87_RS02870	600562..600714	-	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
-	600763..600820	+	58	-	-	Antitoxin
KFU87_RS02875	601300..602466	+	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
KFU87_RS02880	602532..603431	+	900	WP_001300855.1	transcriptional activator NhaR	-
KFU87_RS02885	603470..604428	-	959	Protein_556	fimbrial family protein	-
KFU87_RS02890	604441..605793	-	1353	Protein_557	fimbria/pilus outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T201104 WP_000809168.1 NZ_CP074019:c600714-600562 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T201104 NZ_CP098219:727494-727871 [Escherichia coli]
ATGAAAACATTACCTGATACACACGTACGGAAGGTATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGTACCGACCTGCCGGGATTC
AGCGCCTGTACCCACTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCCGGGCAACAGGCCTGATGATCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGGAAGCATCCGGAGGCGAAACGATGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT201104 NZ_CP074019:600763-600820 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin