Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yafN-yafO (relBE)/YafO-YafN |
Location | 3671469..3672163 | Replicon | chromosome |
Accession | NZ_CP074005 | ||
Organism | Escherichia coli strain PI12 |
Toxin (Protein)
Gene name | yafO | Uniprot ID | S1EXB8 |
Locus tag | KFU69_RS17855 | Protein ID | WP_001263493.1 |
Coordinates | 3671469..3671867 (-) | Length | 133 a.a. |
Antitoxin (Protein)
Gene name | yafN | Uniprot ID | S1FJN6 |
Locus tag | KFU69_RS17860 | Protein ID | WP_000554757.1 |
Coordinates | 3671870..3672163 (-) | Length | 98 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
- (3667129) | 3667129..3667209 | - | 81 | NuclAT_8 | - | - |
- (3667129) | 3667129..3667209 | - | 81 | NuclAT_8 | - | - |
- (3667129) | 3667129..3667209 | - | 81 | NuclAT_8 | - | - |
- (3667129) | 3667129..3667209 | - | 81 | NuclAT_8 | - | - |
KFU69_RS17825 (3666469) | 3666469..3667713 | - | 1245 | WP_000189541.1 | esterase FrsA | - |
KFU69_RS17830 (3667805) | 3667805..3668263 | - | 459 | WP_001291990.1 | xanthine phosphoribosyltransferase | - |
KFU69_RS17835 (3668524) | 3668524..3669981 | + | 1458 | WP_001293003.1 | cytosol nonspecific dipeptidase | - |
KFU69_RS17840 (3670038) | 3670038..3670559 | - | 522 | Protein_3493 | peptide chain release factor H | - |
KFU69_RS17845 (3670558) | 3670558..3670761 | - | 204 | Protein_3494 | RtcB family protein | - |
KFU69_RS17850 (3671007) | 3671007..3671459 | - | 453 | WP_001059847.1 | GNAT family N-acetyltransferase | - |
KFU69_RS17855 (3671469) | 3671469..3671867 | - | 399 | WP_001263493.1 | type II toxin-antitoxin system mRNA interferase toxin YafO | Toxin |
KFU69_RS17860 (3671870) | 3671870..3672163 | - | 294 | WP_000554757.1 | type I toxin-antitoxin system antitoxin YafN | Antitoxin |
KFU69_RS17865 (3672215) | 3672215..3673270 | - | 1056 | WP_001226164.1 | DNA polymerase IV | - |
KFU69_RS17870 (3673341) | 3673341..3673757 | - | 417 | Protein_3499 | OmpA family protein | - |
KFU69_RS17880 (3674572) | 3674572..3674775 | + | 204 | WP_001037608.1 | type II toxin-antitoxin system YafQ family toxin | - |
KFU69_RS17885 (3674931) | 3674931..3675671 | + | 741 | WP_001225679.1 | peptidoglycan meso-diaminopimelic acid protein amidase | - |
KFU69_RS17890 (3675642) | 3675642..3676409 | - | 768 | WP_000333379.1 | class II glutamine amidotransferase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | ykgK/ecpR / gmhA/lpcA | 3650311..3689532 | 39221 | |
- | flank | IS/Tn | - | - | 3673774..3674151 | 377 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 133 a.a. Molecular weight: 15472.83 Da Isoelectric Point: 8.0949
>T201048 WP_001263493.1 NZ_CP074005:c3671867-3671469 [Escherichia coli]
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
MRVFKTKLIRLQLTAEELDALTADFISYKRDGVLPDIFGRDALYDDSFTWPLIKFERVAHIHLANVNNPFPPQLRQFSRT
NDEAHLVYCQGAFDEQAWLLIAILKPEPHKQARDNNQMHKIGKMAEAFRMRF
Download Length: 399 bp
>T201048 NZ_CP098211:c4302065-4301715 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 98 a.a. Molecular weight: 11233.81 Da Isoelectric Point: 5.9050
>AT201048 WP_000554757.1 NZ_CP074005:c3672163-3671870 [Escherichia coli]
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
MHRILAEKSVNITELRKNPAKYFIDQPVAVLSNNRPAGYLLSASAFEALMDMLAEQEEKKPIKARFRPSAARLEEITRRA
EKYLNDMTDDDFNDFKE
Download Length: 294 bp
>AT201048 NZ_CP098211:c4302310-4302059 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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