Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1876728..1877230 | Replicon | chromosome |
| Accession | NZ_CP074005 | ||
| Organism | Escherichia coli strain PI12 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | KFU69_RS08845 | Protein ID | WP_000767829.1 |
| Coordinates | 1876976..1877230 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | KFU69_RS08840 | Protein ID | WP_001259255.1 |
| Coordinates | 1876728..1876979 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFU69_RS08815 (1871906) | 1871906..1872973 | - | 1068 | WP_198478861.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| KFU69_RS08820 (1872973) | 1872973..1874043 | - | 1071 | WP_000108919.1 | histidinol-phosphate transaminase | - |
| KFU69_RS08825 (1874040) | 1874040..1875344 | - | 1305 | WP_152068866.1 | histidinol dehydrogenase | - |
| KFU69_RS08830 (1875350) | 1875350..1876249 | - | 900 | WP_001297349.1 | ATP phosphoribosyltransferase | - |
| KFU69_RS08835 (1876395) | 1876395..1876445 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| KFU69_RS08840 (1876728) | 1876728..1876979 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| KFU69_RS08845 (1876976) | 1876976..1877230 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| KFU69_RS08850 (1877313) | 1877313..1878137 | + | 825 | WP_000754763.1 | SDR family oxidoreductase | - |
| KFU69_RS08855 (1878183) | 1878183..1879112 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| KFU69_RS08860 (1879327) | 1879327..1879389 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| KFU69_RS08865 (1879379) | 1879379..1880737 | + | 1359 | WP_064529416.1 | putrescine/proton symporter PlaP | - |
| KFU69_RS08870 (1880916) | 1880916..1881974 | + | 1059 | WP_000492312.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| KFU69_RS08875 (1881988) | 1881988..1882215 | + | 228 | WP_000985278.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T201036 WP_000767829.1 NZ_CP074005:1876976-1877230 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T201036 NZ_CP098211:1846806-1847060 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT201036 WP_001259255.1 NZ_CP074005:1876728-1876979 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT201036 NZ_CP098211:1846558-1846809 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|