Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 720471..721164 Replicon chromosome
Accession NZ_CP074005
Organism Escherichia coli strain PI12

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KFU69_RS03480 Protein ID WP_000415584.1
Coordinates 720471..720767 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KFU69_RS03485 Protein ID WP_000650107.1
Coordinates 720769..721164 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU69_RS03445 (715559) 715559..715873 - 315 WP_000958598.1 putative quinol monooxygenase -
KFU69_RS03450 (715904) 715904..716485 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KFU69_RS03455 (716804) 716804..717136 + 333 WP_000917684.1 DUF2645 family protein -
KFU69_RS03460 (717182) 717182..718531 - 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
KFU69_RS03465 (718528) 718528..719187 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KFU69_RS03470 (719339) 719339..719731 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KFU69_RS03475 (719784) 719784..720266 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KFU69_RS03480 (720471) 720471..720767 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KFU69_RS03485 (720769) 720769..721164 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KFU69_RS03490 (721297) 721297..722904 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KFU69_RS03495 (723042) 723042..725300 + 2259 WP_032161229.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T201032 WP_000415584.1 NZ_CP074005:720471-720767 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T201032 NZ_CP098211:943835-944242 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT201032 WP_000650107.1 NZ_CP074005:720769-721164 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT201032 NZ_CP098211:943588-943854 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References