Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1770183..1770685 | Replicon | chromosome |
| Accession | NZ_CP074001 | ||
| Organism | Escherichia coli strain PM4 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | D3GZ85 |
| Locus tag | KFU80_RS08520 | Protein ID | WP_000767820.1 |
| Coordinates | 1770431..1770685 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | KFU80_RS08515 | Protein ID | WP_001259255.1 |
| Coordinates | 1770183..1770434 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFU80_RS08490 (1765360) | 1765360..1766427 | - | 1068 | WP_072668050.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| KFU80_RS08495 (1766427) | 1766427..1767497 | - | 1071 | WP_000108928.1 | histidinol-phosphate transaminase | - |
| KFU80_RS08500 (1767494) | 1767494..1768798 | - | 1305 | WP_000009586.1 | histidinol dehydrogenase | - |
| KFU80_RS08505 (1768804) | 1768804..1769703 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
| KFU80_RS08510 (1769849) | 1769849..1769899 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| KFU80_RS08515 (1770183) | 1770183..1770434 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| KFU80_RS08520 (1770431) | 1770431..1770685 | + | 255 | WP_000767820.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| KFU80_RS08525 (1770768) | 1770768..1771592 | + | 825 | WP_000754756.1 | SDR family oxidoreductase | - |
| KFU80_RS08530 (1771638) | 1771638..1772567 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| KFU80_RS08535 (1772782) | 1772782..1772844 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| KFU80_RS08540 (1772834) | 1772834..1774192 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| KFU80_RS08545 (1774371) | 1774371..1775429 | + | 1059 | WP_000492324.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| KFU80_RS08550 (1775443) | 1775443..1775670 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10182.64 Da Isoelectric Point: 8.0353
>T201012 WP_000767820.1 NZ_CP074001:1770431-1770685 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKIIELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKIIELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T201012 NZ_CP098210:c917360-916983 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGTACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGTACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGTCTGATGACCCGCAG
CAACTACAGAACGGTAAATAACATTACCCGGGGGAAGCATCCGGAGGCGAAACAATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT201012 WP_001259255.1 NZ_CP074001:1770183-1770434 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT201012 NZ_CP098210:c917818-917450 [Escherichia coli]
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTAACAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
GTGTCAGACACACTCTCCGGGACAACGCATCCCGATGACAATCACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTAACAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | D3GZ85 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| PDB | 2A6Q | |
| AlphaFold DB | A0A7U9LNR0 |