Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 694298..694991 Replicon chromosome
Accession NZ_CP074001
Organism Escherichia coli strain PM4

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KFU80_RS03435 Protein ID WP_000415584.1
Coordinates 694298..694594 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KFU80_RS03440 Protein ID WP_000650107.1
Coordinates 694596..694991 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU80_RS03400 (689386) 689386..689700 - 315 WP_000958598.1 putative quinol monooxygenase -
KFU80_RS03405 (689731) 689731..690312 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KFU80_RS03410 (690631) 690631..690963 + 333 WP_000917684.1 DUF2645 family protein -
KFU80_RS03415 (691009) 691009..692358 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KFU80_RS03420 (692355) 692355..693014 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KFU80_RS03425 (693166) 693166..693558 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KFU80_RS03430 (693611) 693611..694093 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KFU80_RS03435 (694298) 694298..694594 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KFU80_RS03440 (694596) 694596..694991 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KFU80_RS03445 (695124) 695124..696731 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KFU80_RS03450 (696869) 696869..699127 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T201009 WP_000415584.1 NZ_CP074001:694298-694594 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T201009 NZ_CP098210:469952-470125 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT201009 WP_000650107.1 NZ_CP074001:694596-694991 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT201009 NZ_CP098210:469628-469924 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCATTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References