Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 725125..725818 Replicon chromosome
Accession NZ_CP073962
Organism Escherichia coli strain MB31

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KFU79_RS03535 Protein ID WP_000415584.1
Coordinates 725125..725421 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KFU79_RS03540 Protein ID WP_000650107.1
Coordinates 725423..725818 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU79_RS03500 (720213) 720213..720527 - 315 WP_000958598.1 putative quinol monooxygenase -
KFU79_RS03505 (720558) 720558..721139 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KFU79_RS03510 (721458) 721458..721790 + 333 WP_000917685.1 DUF2645 family protein -
KFU79_RS03515 (721836) 721836..723185 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KFU79_RS03520 (723182) 723182..723841 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KFU79_RS03525 (723993) 723993..724385 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KFU79_RS03530 (724438) 724438..724920 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KFU79_RS03535 (725125) 725125..725421 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KFU79_RS03540 (725423) 725423..725818 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KFU79_RS03545 (725951) 725951..727558 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KFU79_RS03550 (727696) 727696..729954 + 2259 WP_032329482.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T200829 WP_000415584.1 NZ_CP073962:725125-725421 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T200829 NZ_CP098183:c2156704-2156510 [Escherichia coli]
ATGAGATATGACAATGTTAAACCATGTCCATTTTGTGGTTGTCCATCAGTAACGGTGAAAGCCATTTCAGGATATTACCG
AGCGAAGTGTAACGGATGCGAATCCCGAACCGATTATGGTGGAAGTGAAAAAGAAGCACTCGAAAGATGGAATAAACGAA
CCACTGGAAATAATAATGGAGGTGTTCATGTATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT200829 WP_000650107.1 NZ_CP073962:725423-725818 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT200829 NZ_CP098183:2156333-2156511 [Escherichia coli]
GAGGACTGAAGTTTCTCGCAATTAAAATTTATCAGTTTTACTTTCTGCTCTCTGGAAACGCCTGCTTCTTTTTTACCTGA
GAGCATTTTTTCGCATTCTGATTTCGTTAGTTTAGATTTTGAATATCTTGTCCAGTTAGTAGAAGTGCCACCTTCCTTTT
CAATAGTGGCGGTAATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References