Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1791133..1791635 | Replicon | chromosome |
| Accession | NZ_CP073953 | ||
| Organism | Escherichia coli strain MB49 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | KFU90_RS08520 | Protein ID | WP_000767829.1 |
| Coordinates | 1791381..1791635 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | - |
| Locus tag | KFU90_RS08515 | Protein ID | WP_001610372.1 |
| Coordinates | 1791133..1791384 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFU90_RS08490 (1786311) | 1786311..1787378 | - | 1068 | WP_000080141.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
| KFU90_RS08495 (1787378) | 1787378..1788448 | - | 1071 | WP_000108941.1 | histidinol-phosphate transaminase | - |
| KFU90_RS08500 (1788445) | 1788445..1789749 | - | 1305 | WP_001367667.1 | histidinol dehydrogenase | - |
| KFU90_RS08505 (1789755) | 1789755..1790654 | - | 900 | WP_000131792.1 | ATP phosphoribosyltransferase | - |
| KFU90_RS08510 (1790800) | 1790800..1790850 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
| KFU90_RS08515 (1791133) | 1791133..1791384 | + | 252 | WP_001610372.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| KFU90_RS08520 (1791381) | 1791381..1791635 | + | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| KFU90_RS08525 (1791718) | 1791718..1792542 | + | 825 | WP_000754737.1 | SDR family oxidoreductase | - |
| KFU90_RS08530 (1792588) | 1792588..1793517 | + | 930 | WP_000803366.1 | LysR substrate-binding domain-containing protein | - |
| KFU90_RS08535 (1793732) | 1793732..1793794 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
| KFU90_RS08540 (1793784) | 1793784..1795142 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| KFU90_RS08545 (1795322) | 1795322..1796380 | + | 1059 | WP_000492330.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| KFU90_RS08550 (1796394) | 1796394..1796621 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T200774 WP_000767829.1 NZ_CP073953:1791381-1791635 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T200774 NZ_CP098169:2239234-2239602 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGACAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGACAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9289.55 Da Isoelectric Point: 4.7954
>AT200774 WP_001610372.1 NZ_CP073953:1791133-1791384 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLIDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLIDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT200774 NZ_CP098169:2239016-2239237 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|