Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/-
Location 1978164..1978666 Replicon chromosome
Accession HG738867
Organism Escherichia coli str. K-12 substr. MC4100

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag BN896_1807 Protein ID CDJ72387.1
Coordinates 1978164..1978418 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag BN896_1808 Protein ID CDJ72388.1
Coordinates 1978415..1978666 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BN896_1802 1973179..1973406 - 228 CDJ72382.1 hypothetical protein -
BN896_1803 1973420..1974478 - 1059 CDJ72383.1 putative inner membrane protein -
BN896_1804 1974657..1976015 - 1359 CDJ72384.1 putative amino-acid transporter -
BN896_1805 1976282..1977211 - 930 CDJ72385.1 putative DNA-binding transcriptional regulator -
BN896_1806 1977257..1978081 - 825 CDJ72386.1 putative epimerase, with NAD(P)-binding Rossmann-fold domain -
BN896_1807 1978164..1978418 - 255 CDJ72387.1 toxin of the YoeB-YefM toxin-antitoxin system Toxin
BN896_1808 1978415..1978666 - 252 CDJ72388.1 antitoxin YefM Antitoxin
BN896_1809 1978949..1978999 + 51 CDJ72389.1 his operon leader peptide -
BN896_1810 1979145..1980044 + 900 CDJ72390.1 ATP phosphoribosyltransferase -
BN896_1811 1980050..1981354 + 1305 CDJ72391.1 histidinol dehydrogenase -
BN896_1812 1981351..1982421 + 1071 CDJ72392.1 histidinol-phosphate aminotransferase -
BN896_1813 1982421..1983488 + 1068 CDJ72393.1 imidazole glycerol-phosphate dehydratase/histidinol phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T20077 CDJ72387.1 HG738867:c1978418-1978164 [Escherichia coli str. K-12 substr. MC4100]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T20077 HG738867:c1978418-1978164 [Escherichia coli str. K-12 substr. MC4100]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT20077 CDJ72388.1 HG738867:c1978666-1978415 [Escherichia coli str. K-12 substr. MC4100]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT20077 HG738867:c1978666-1978415 [Escherichia coli str. K-12 substr. MC4100]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References