Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 46868..47137 | Replicon | plasmid pYLMB51a |
| Accession | NZ_CP073947 | ||
| Organism | Escherichia coli strain MB51 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | KFU68_RS23725 | Protein ID | WP_001372321.1 |
| Coordinates | 47012..47137 (+) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 46868..46933 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFU68_RS23680 (41890) | 41890..42162 | + | 273 | WP_072118979.1 | hypothetical protein | - |
| KFU68_RS23685 (42403) | 42403..42609 | + | 207 | WP_000275858.1 | hypothetical protein | - |
| KFU68_RS23690 (42635) | 42635..43174 | + | 540 | WP_001825195.1 | single-stranded DNA-binding protein | - |
| KFU68_RS23695 (43237) | 43237..43470 | + | 234 | WP_000005990.1 | DUF905 family protein | - |
| KFU68_RS23700 (43536) | 43536..45494 | + | 1959 | WP_001825193.1 | ParB/RepB/Spo0J family partition protein | - |
| KFU68_RS23705 (45549) | 45549..45983 | + | 435 | WP_000845953.1 | conjugation system SOS inhibitor PsiB | - |
| KFU68_RS23710 (45980) | 45980..46742 | + | 763 | Protein_57 | plasmid SOS inhibition protein A | - |
| KFU68_RS23715 (46711) | 46711..46899 | - | 189 | WP_001299721.1 | hypothetical protein | - |
| - (46868) | 46868..46933 | + | 66 | NuclAT_1 | - | - |
| - (46868) | 46868..46933 | - | 66 | NuclAT_0 | - | Antitoxin |
| - (46868) | 46868..46933 | - | 66 | NuclAT_0 | - | Antitoxin |
| - (46711) | 46711..46935 | + | 225 | NuclAT_0 | - | - |
| - (46711) | 46711..46935 | + | 225 | NuclAT_0 | - | - |
| - (46711) | 46711..46935 | + | 225 | NuclAT_0 | - | - |
| - (46711) | 46711..46935 | + | 225 | NuclAT_0 | - | - |
| - (46711) | 46711..46935 | - | 225 | NuclAT_0 | - | - |
| KFU68_RS23720 (46921) | 46921..47070 | + | 150 | Protein_59 | plasmid maintenance protein Mok | - |
| KFU68_RS23725 (47012) | 47012..47137 | + | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| KFU68_RS23730 (47357) | 47357..47587 | + | 231 | WP_001426396.1 | hypothetical protein | - |
| KFU68_RS23735 (47585) | 47585..47758 | - | 174 | Protein_62 | hypothetical protein | - |
| KFU68_RS23740 (47828) | 47828..48034 | + | 207 | WP_000547968.1 | hypothetical protein | - |
| KFU68_RS23745 (48059) | 48059..48346 | + | 288 | WP_000107544.1 | hypothetical protein | - |
| KFU68_RS23750 (48464) | 48464..49285 | + | 822 | WP_001234469.1 | DUF932 domain-containing protein | - |
| KFU68_RS23755 (49582) | 49582..50229 | - | 648 | WP_031943493.1 | transglycosylase SLT domain-containing protein | - |
| KFU68_RS23760 (50506) | 50506..50889 | + | 384 | WP_000124981.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| KFU68_RS23765 (51080) | 51080..51766 | + | 687 | WP_000332484.1 | PAS domain-containing protein | - |
| KFU68_RS23770 (51861) | 51861..52088 | + | 228 | WP_001254386.1 | conjugal transfer relaxosome protein TraY | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T200744 WP_001372321.1 NZ_CP073947:47012-47137 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T200744 NZ_CP098165:368365-369282 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCTGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCTGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTTTCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG
Antitoxin
Download Length: 66 bp
>AT200744 NZ_CP073947:c46933-46868 [Escherichia coli]
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT
GTGGACTAGACATAGGGATGCCTCGTGGTGGTTAATGAAAATTAACTTACTACGGGGCTATCTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
