Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 712498..713191 Replicon chromosome
Accession NZ_CP073946
Organism Escherichia coli strain MB51

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KFU68_RS03460 Protein ID WP_000415584.1
Coordinates 712498..712794 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KFU68_RS03465 Protein ID WP_000650107.1
Coordinates 712796..713191 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU68_RS03425 (707586) 707586..707900 - 315 WP_000958598.1 putative quinol monooxygenase -
KFU68_RS03430 (707931) 707931..708512 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KFU68_RS03435 (708831) 708831..709163 + 333 WP_000917684.1 DUF2645 family protein -
KFU68_RS03440 (709209) 709209..710558 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KFU68_RS03445 (710555) 710555..711214 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KFU68_RS03450 (711366) 711366..711758 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KFU68_RS03455 (711811) 711811..712293 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KFU68_RS03460 (712498) 712498..712794 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KFU68_RS03465 (712796) 712796..713191 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KFU68_RS03470 (713324) 713324..714931 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KFU68_RS03475 (715069) 715069..717327 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T200720 WP_000415584.1 NZ_CP073946:712498-712794 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T200720 NZ_CP098159:2012918-2013020 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT200720 WP_000650107.1 NZ_CP073946:712796-713191 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT200720 NZ_CP098159:c2013027-2012882 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References