Detailed information of TA system TA200686

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 3818397..3818655
• Replicon: chromosome
• Accession: NZ_CP073939
• Organism: Escherichia coli strain MB53

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: KFU83_RS18590
• Protein ID: WP_000809168.1
• Coordinates: 3818503..3818655 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	3818397..3818454 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KFU83_RS18565	3814098..3814316	-	219	WP_001300728.1	DUF2575 family protein	-
KFU83_RS18570	3814419..3814682	+	264	WP_001274021.1	30S ribosomal protein S20	-
KFU83_RS18580	3815786..3816685	-	900	WP_257188386.1	transcriptional activator NhaR	-
KFU83_RS18585	3816751..3817917	-	1167	WP_000681368.1	Na+/H+ antiporter NhaA	-
-	3818397..3818454	-	58	-	-	Antitoxin
KFU83_RS18590	3818503..3818655	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
KFU83_RS18595	3818733..3819845	+	1113	Protein_3639	IS4-like element IS421 family transposase	-
KFU83_RS18600	3820108..3821238	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
KFU83_RS18605	3821327..3823243	-	1917	WP_000516135.1	molecular chaperone DnaK	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	3814946..3825265	10319

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T200686 WP_000809168.1 NZ_CP073939:3818503-3818655 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T200686 NZ_CP098141:c4534691-4534158 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGTGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAAGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT200686 NZ_CP073939:c3818454-3818397 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin