Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 709972..710665 Replicon chromosome
Accession NZ_CP073936
Organism Escherichia coli strain MB56

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag KFU61_RS03460 Protein ID WP_000415584.1
Coordinates 709972..710268 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag KFU61_RS03465 Protein ID WP_000650107.1
Coordinates 710270..710665 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU61_RS03425 (705060) 705060..705374 - 315 WP_000958598.1 putative quinol monooxygenase -
KFU61_RS03430 (705405) 705405..705986 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
KFU61_RS03435 (706305) 706305..706637 + 333 WP_000917684.1 DUF2645 family protein -
KFU61_RS03440 (706683) 706683..708032 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
KFU61_RS03445 (708029) 708029..708688 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
KFU61_RS03450 (708840) 708840..709232 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
KFU61_RS03455 (709285) 709285..709767 + 483 WP_000183505.1 GyrI-like domain-containing protein -
KFU61_RS03460 (709972) 709972..710268 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
KFU61_RS03465 (710270) 710270..710665 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
KFU61_RS03470 (710798) 710798..712405 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
KFU61_RS03475 (712543) 712543..714801 + 2259 WP_001281881.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T200647 WP_000415584.1 NZ_CP073936:709972-710268 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T200647 NZ_CP098131:c1574610-1574326 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT200647 WP_000650107.1 NZ_CP073936:710270-710665 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT200647 NZ_CP098131:c1574842-1574600 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References