Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2472048..2472686 Replicon chromosome
Accession NZ_CP073929
Organism Escherichia coli strain MB64

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag KFU91_RS11780 Protein ID WP_000813794.1
Coordinates 2472510..2472686 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag KFU91_RS11775 Protein ID WP_001270286.1
Coordinates 2472048..2472464 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFU91_RS11755 (2467200) 2467200..2468141 - 942 WP_001251319.1 ABC transporter permease -
KFU91_RS11760 (2468142) 2468142..2469155 - 1014 WP_104769175.1 ABC transporter ATP-binding protein -
KFU91_RS11765 (2469173) 2469173..2470318 - 1146 WP_000047429.1 ABC transporter substrate-binding protein -
KFU91_RS11770 (2470560) 2470560..2471969 - 1410 WP_000760625.1 PLP-dependent aminotransferase family protein -
KFU91_RS11775 (2472048) 2472048..2472464 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
KFU91_RS11780 (2472510) 2472510..2472686 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
KFU91_RS11785 (2472908) 2472908..2473138 + 231 WP_000494244.1 YncJ family protein -
KFU91_RS11790 (2473230) 2473230..2475191 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
KFU91_RS11795 (2475264) 2475264..2475800 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
KFU91_RS11800 (2475853) 2475853..2477067 + 1215 WP_001326689.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2477107..2478255 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T200608 WP_000813794.1 NZ_CP073929:c2472686-2472510 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T200608 NZ_CP098040:c1930162-1929845 [Providencia rettgeri]
TTGACTCAGAAGCCAAGTAATAAGCGAGCTAAGCAACCAAGGCAGGTTGCTTATACACCAACGTTTAAGAAGTCATGGGA
ACGATATAACCGAGCGGGCCGTAGGGATATGAATGCGGCTGTTCTCGTTATGGAAATACTGTTTTCTCAAAAAATAATAC
CAAAAGAATATCTTGACCATGAATTAGAAGGTCATGAATGGCAAGGAGCTAGGGAGCTTCATATTGGTGGTGATTTCTTA
CTGGTTTATCGCTTGTCAGATAAAGGTAATTTAATCACTTTCGTTGATATTGGTTCGCACAGTGAATTATTTGGTTAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT200608 WP_001270286.1 NZ_CP073929:c2472464-2472048 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT200608 NZ_CP098040:c1930430-1930143 [Providencia rettgeri]
ATGTCAACACTATTGAAAACAACAGATGTTCGTAGTCGAATTGATGAACAATTAAAAGCGGAAGCCACGAGTGTATTACA
AGATTGTGGTTTGACTATTAGCGCAGCTATTCGTTTGTTTTTAGAACAAGTAGTTCAAGAGCAAAGAGTTCCCTTTGAAA
TCAAACGTAAGCAACCTTCGCTGAAAACTACACTAGCGTTGAAAGAAGCTAAAGCTATTGAGCAGCACTACGATTCAATT
AACGAAATGATGGTGGAGTTAAGCAAAGTTGACTCAGAAGCCAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References