Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
Location | 1889280..1889782 | Replicon | chromosome |
Accession | NZ_CP073924 | ||
Organism | Escherichia coli strain MB165 |
Toxin (Protein)
Gene name | yoeB | Uniprot ID | A0A8E0FJZ4 |
Locus tag | KFU71_RS09045 | Protein ID | WP_000767833.1 |
Coordinates | 1889528..1889782 (+) | Length | 85 a.a. |
Antitoxin (Protein)
Gene name | yefM | Uniprot ID | S1Q063 |
Locus tag | KFU71_RS09040 | Protein ID | WP_001259255.1 |
Coordinates | 1889280..1889531 (+) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KFU71_RS09015 (1884459) | 1884459..1885526 | - | 1068 | WP_072652219.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
KFU71_RS09020 (1885526) | 1885526..1886596 | - | 1071 | WP_000108969.1 | histidinol-phosphate transaminase | - |
KFU71_RS09025 (1886593) | 1886593..1887897 | - | 1305 | WP_072652220.1 | histidinol dehydrogenase | - |
KFU71_RS09030 (1887903) | 1887903..1888802 | - | 900 | WP_000131782.1 | ATP phosphoribosyltransferase | - |
KFU71_RS09035 (1888948) | 1888948..1888998 | - | 51 | WP_001364200.1 | his operon leader peptide | - |
KFU71_RS09040 (1889280) | 1889280..1889531 | + | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
KFU71_RS09045 (1889528) | 1889528..1889782 | + | 255 | WP_000767833.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
KFU71_RS09050 (1889865) | 1889865..1890689 | + | 825 | WP_032202495.1 | SDR family oxidoreductase | - |
KFU71_RS09055 (1890735) | 1890735..1891664 | + | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
KFU71_RS09060 (1891879) | 1891879..1891941 | + | 63 | WP_010723108.1 | membrane protein YoeI | - |
KFU71_RS09065 (1891931) | 1891931..1893289 | + | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
KFU71_RS09070 (1893468) | 1893468..1894526 | + | 1059 | WP_000492305.1 | thiosulfate utilization transporter TsuA/YeeE | - |
KFU71_RS09075 (1894540) | 1894540..1894767 | + | 228 | WP_000985273.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10173.54 Da Isoelectric Point: 8.0353
>T200546 WP_000767833.1 NZ_CP073924:1889528-1889782 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPESLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPESLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T200546 NZ_CP097896:992042-993376 [Pectobacterium actinidiae]
ATGCCTCGAATACAACAGCGTTTAGCAATATGGATGAATGGAATTCAAGTGGGATTCTGGGAAAAGAGCCGAGGCGAAGA
TAGGTTGCAATATCTTCCCGAATGGATCGCTGATGAACAAGGAAGACCTTTATCGCTTTCTTTGCTTTTCACCCCCGGTA
ATCAGATTTGGCGGGGCAATGTGGTACGCGACTATTTTGATAATTTATTGCCTGACAGCGAAGGTATACGCAGGCGTTTA
GCGACGCGTTACCACGCTGATAGCCTTGAGCCTTTTGATCTGTTGGCTGAGCTGGGGAGAGACTGTGTTGGTGCGATACA
GTTGCTGAATGGTAATGAGGAGCCTACAGATCTCTTTTCCGTAAAGTATCGCCCGATTTGTGACGCAGAGATTGCCGCTA
TATTGCGTAATACAACAGCGGCATTGTTGCCAGGTCGGCAGGATGATACTGACGATTTACGTTTATCGATTGCCGGTGCG
CAGGAAAAAACGGCTTTACTCTGGCATGAAAGGCAATGGTGTTTGCCAGAAGGGAGTACCCCTACGACGCATATTTTCAA
GTTACCACTCGGGCTAGTGGGTAATATGCAAGCGGATATGAGTACGTCGGTTGAAAATGAATGGCTGTGTTCTTTGATCC
TTAAGGAATATGGAATTCCTGTTGCAAAAACACAGATTGCGCAGTTTGAAGATCAGAAAGTATTGGTTGTTGAGCGTTTT
GACAGAAGATGGTCAAGCGATCAGCAATGGATCATTCGCTTGCCACAAGAGGATATGTGTCAGGCTCTGGGTGTTTCCCC
GCTACGAAAATACCAGTCTGATGGTGGGCCAGGGATTTCCGATATTATGACCATACTGAGTCATTCAGAGCAGGCAGAGC
AGGACAAAGCGCAGTTTTTCAGGGCGCAAATTATTTTCTGGCTGATAGCGGCTACTGATGGGCACGCCAAAAATTTCAGT
ATCGCTATTGAGCCACAAGGTCGCTATCACCTTACGCCTCTTTATGATGTTTTATCGGCATGGCCGGTCATTGGTCCGCG
TAATAACCAGATTTCCTGGCAGAAGTGCAAGCTGGCAATGGCTGTTCGGGGTAGTAGTAATTATTACCATCTGTACAGAA
TTCAACGGCGGCATTGGGTCAATCATGGTGAATTAACTGGTCTGGGTAGACGACAGGTTGAAGCCATGATGGATGATATT
ATCTTCAGGACACCTGAGGTTATTGAACGTGTATCTTCGTTGCTGCCTGAGTCATTCTCACCAGAGCTTGCGGAATGTGT
TTTTGACGGTATGCGACAACAGTGTGGTCGGTTACAAGAATTGCACCGTAAATAG
ATGCCTCGAATACAACAGCGTTTAGCAATATGGATGAATGGAATTCAAGTGGGATTCTGGGAAAAGAGCCGAGGCGAAGA
TAGGTTGCAATATCTTCCCGAATGGATCGCTGATGAACAAGGAAGACCTTTATCGCTTTCTTTGCTTTTCACCCCCGGTA
ATCAGATTTGGCGGGGCAATGTGGTACGCGACTATTTTGATAATTTATTGCCTGACAGCGAAGGTATACGCAGGCGTTTA
GCGACGCGTTACCACGCTGATAGCCTTGAGCCTTTTGATCTGTTGGCTGAGCTGGGGAGAGACTGTGTTGGTGCGATACA
GTTGCTGAATGGTAATGAGGAGCCTACAGATCTCTTTTCCGTAAAGTATCGCCCGATTTGTGACGCAGAGATTGCCGCTA
TATTGCGTAATACAACAGCGGCATTGTTGCCAGGTCGGCAGGATGATACTGACGATTTACGTTTATCGATTGCCGGTGCG
CAGGAAAAAACGGCTTTACTCTGGCATGAAAGGCAATGGTGTTTGCCAGAAGGGAGTACCCCTACGACGCATATTTTCAA
GTTACCACTCGGGCTAGTGGGTAATATGCAAGCGGATATGAGTACGTCGGTTGAAAATGAATGGCTGTGTTCTTTGATCC
TTAAGGAATATGGAATTCCTGTTGCAAAAACACAGATTGCGCAGTTTGAAGATCAGAAAGTATTGGTTGTTGAGCGTTTT
GACAGAAGATGGTCAAGCGATCAGCAATGGATCATTCGCTTGCCACAAGAGGATATGTGTCAGGCTCTGGGTGTTTCCCC
GCTACGAAAATACCAGTCTGATGGTGGGCCAGGGATTTCCGATATTATGACCATACTGAGTCATTCAGAGCAGGCAGAGC
AGGACAAAGCGCAGTTTTTCAGGGCGCAAATTATTTTCTGGCTGATAGCGGCTACTGATGGGCACGCCAAAAATTTCAGT
ATCGCTATTGAGCCACAAGGTCGCTATCACCTTACGCCTCTTTATGATGTTTTATCGGCATGGCCGGTCATTGGTCCGCG
TAATAACCAGATTTCCTGGCAGAAGTGCAAGCTGGCAATGGCTGTTCGGGGTAGTAGTAATTATTACCATCTGTACAGAA
TTCAACGGCGGCATTGGGTCAATCATGGTGAATTAACTGGTCTGGGTAGACGACAGGTTGAAGCCATGATGGATGATATT
ATCTTCAGGACACCTGAGGTTATTGAACGTGTATCTTCGTTGCTGCCTGAGTCATTCTCACCAGAGCTTGCGGAATGTGT
TTTTGACGGTATGCGACAACAGTGTGGTCGGTTACAAGAATTGCACCGTAAATAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT200546 WP_001259255.1 NZ_CP073924:1889280-1889531 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT200546 NZ_CP097896:991732-992037 [Pectobacterium actinidiae]
ATGAATACAGTCTATCCGTTGAAAACCTTGAATCAGTTGCGCCCATTGCTGATTGGCTTTCGCAAGGCTAAAGGACTGAC
GCAAAAAGACGTGTCTGAAAGGTTAGGTGTAACACAACAAACCTATGCCCGTTTGGAAGCAAACCCCGGAAGTGCCAGTA
TTGAGCGCTTGTTTAAAGTGCTCACCGTTCTGGGGGTTGAGGTAGTGCTGTCTTCTGGACCAAGAGTACATTTCTCGATG
TCGTCCTCAACAATGGAAGAGCCAGAAAAGCCAATAGACTCACCCGCCAGACGGGAAAAATGGTGA
ATGAATACAGTCTATCCGTTGAAAACCTTGAATCAGTTGCGCCCATTGCTGATTGGCTTTCGCAAGGCTAAAGGACTGAC
GCAAAAAGACGTGTCTGAAAGGTTAGGTGTAACACAACAAACCTATGCCCGTTTGGAAGCAAACCCCGGAAGTGCCAGTA
TTGAGCGCTTGTTTAAAGTGCTCACCGTTCTGGGGGTTGAGGTAGTGCTGTCTTCTGGACCAAGAGTACATTTCTCGATG
TCGTCCTCAACAATGGAAGAGCCAGAAAAGCCAATAGACTCACCCGCCAGACGGGAAAAATGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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