Detailed information of TA system TA200534

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-YefM
• Location: 3933214..3933716
• Replicon: chromosome
• Accession: NZ_CP073914
• Organism: Proteus terrae subsp. cibarius strain SH19PTE4

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: KF949_RS18445
• Protein ID: WP_075671248.1
• Coordinates: 3933462..3933716 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: KF949_RS18440
• Protein ID: WP_072068851.1
• Coordinates: 3933214..3933465 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KF949_RS18415 (KF949_18415)	3928805..3929581	+	777	WP_006534565.1	phosphate ABC transporter ATP-binding protein PstB	-
KF949_RS18420 (KF949_18420)	3929596..3930330	+	735	WP_075671254.1	phosphate signaling complex protein PhoU	-
KF949_RS18425 (KF949_18425)	3930546..3931385	+	840	WP_036933789.1	ABC transporter substrate-binding protein	-
KF949_RS18430 (KF949_18430)	3931492..3932229	+	738	WP_075671252.1	amino acid ABC transporter permease	-
KF949_RS18435 (KF949_18435)	3932231..3932983	+	753	WP_075671250.1	amino acid ABC transporter permease	-
KF949_RS18440 (KF949_18440)	3933214..3933465	+	252	WP_072068851.1	YoeB-YefM toxin-antitoxin system antitoxin YefM	Antitoxin
KF949_RS18445 (KF949_18445)	3933462..3933716	+	255	WP_075671248.1	Txe/YoeB family addiction module toxin	Toxin
KF949_RS18450 (KF949_18450)	3933873..3935231	+	1359	WP_075671246.1	NCS2 family permease	-
KF949_RS18455 (KF949_18455)	3935312..3935623	+	312	WP_098941657.1	monooxygenase	-
KF949_RS18460 (KF949_18460)	3935673..3936221	-	549	WP_211838689.1	GNAT family N-acetyltransferase	-
KF949_RS18465 (KF949_18465)	3936224..3937696	-	1473	WP_075671240.1	glycosyltransferase family 39 protein	-
KF949_RS18470 (KF949_18470)	3937885..3938382	+	498	WP_075671238.1	Der GTPase-activating protein YihI	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10170.78 Da
• Isoelectric Point: 9.9411

>T200534 WP_075671248.1 NZ_CP073914:3933462-3933716 [Proteus terrae subsp. cibarius]
MKLIFSEQSWSDYLYWQQIDKKIIKRINELIKDIKRTPFSGIGKPEPLKHNLAGFWSRRITDEHRLIYRITDSAIEIASC
RYHY

Nucleotide

• Length: 255 bp

>T200534 NZ_CP097884:4279914-4280255 [Escherichia coli str. K-12 substr. MG1655]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9463.77 Da
• Isoelectric Point: 4.4354

>AT200534 WP_072068851.1 NZ_CP073914:3933214-3933465 [Proteus terrae subsp. cibarius]
MKTINYTEARQNLTSIMNETIDDRVPIMITRQKGIPCVLLSLDEYQALEETAYLLRSPANARHLLDSIDELNQGKGIEKD
ITE

Nucleotide

• Length: 252 bp

>AT200534 NZ_CP097884:4279576-4279893 [Escherichia coli str. K-12 substr. MG1655]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA