Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3478592..3479190 Replicon chromosome
Accession NZ_CP073914
Organism Proteus terrae subsp. cibarius strain SH19PTE4

Toxin (Protein)


Gene name higB Uniprot ID Q8KQX9
Locus tag KF949_RS16485 Protein ID WP_000118545.1
Coordinates 3478592..3478915 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KF949_RS16490 Protein ID WP_000058216.1
Coordinates 3478912..3479190 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KF949_RS16455 (KF949_16455) 3474305..3474691 - 387 WP_000180225.1 TraA family conjugative transfer protein -
KF949_RS16460 (KF949_16460) 3474688..3475260 - 573 WP_139057167.1 type IV conjugative transfer system lipoprotein TraV -
KF949_RS16465 (KF949_16465) 3475335..3476624 - 1290 WP_001883765.1 TraB/VirB10 family protein -
KF949_RS16470 (KF949_16470) 3476627..3477523 - 897 WP_211839074.1 type-F conjugative transfer system secretin TraK -
KF949_RS16475 (KF949_16475) 3477507..3478133 - 627 WP_000667169.1 TraE/TraK family type IV conjugative transfer system protein -
KF949_RS16480 (KF949_16480) 3478130..3478411 - 282 WP_000433889.1 type IV conjugative transfer system protein TraL -
KF949_RS16485 (KF949_16485) 3478592..3478915 + 324 WP_000118545.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KF949_RS16490 (KF949_16490) 3478912..3479190 + 279 WP_000058216.1 helix-turn-helix transcriptional regulator Antitoxin
KF949_RS16495 (KF949_16495) 3479216..3479851 - 636 WP_000033753.1 DUF4400 domain-containing protein -
KF949_RS16500 (KF949_16500) 3479838..3480398 - 561 WP_000546510.1 hypothetical protein -
KF949_RS16505 (KF949_16505) 3480408..3482228 - 1821 WP_000661887.1 conjugative transfer system coupling protein TraD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(H) / aadA2 / ere(A) / dfrA32 / aph(3')-Ia / tet(C) - 3343725..3504025 160300


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(14-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-81)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12267.26 Da        Isoelectric Point: 9.4705

>T200531 WP_000118545.1 NZ_CP073914:3478592-3478915 [Proteus terrae subsp. cibarius]
MSWKIDFYDGVEDQILDMPPKIQARMIKLLELMEKHGANLGPPHTESMGDGLFEIRAKAQEGIGRGLFCYLKGNHIYVLH
AFVKKSQKTPKNELNLARDRQKEVQKS

Download         Length: 324 bp

>T200531 NZ_CP097884:3223205-3223312 [Escherichia coli str. K-12 substr. MG1655]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10517.07 Da        Isoelectric Point: 9.9393

>AT200531 WP_000058216.1 NZ_CP073914:3478912-3479190 [Proteus terrae subsp. cibarius]
MSLQKLKQRALANAEVKNEYDKLESEFSFIDQLLTMRTKAGLTQEQVAERMHTQKSNVSRLEKGNANPSWSTLLKYAHAC
GFELTLKPQKMS

Download         Length: 279 bp

>AT200531 NZ_CP097884:c3223158-3223092 [Escherichia coli str. K-12 substr. MG1655]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0X1L383

Antitoxin

Source ID Structure

References