Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type I Classification (family/domain) hok-sok/-
Location 2257..2521 Replicon plasmid pHK31_3
Accession NZ_CP073909
Organism Klebsiella pneumoniae strain HK31

Toxin (Protein)


Gene name pndA Uniprot ID -
Locus tag KFK82_RS28135 Protein ID WP_024179505.1
Coordinates 2369..2521 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 2257..2317 (-)

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFK82_RS28130 (869) 869..2077 - 1209 WP_064148469.1 IncI1-type conjugal transfer protein TrbA -
- (2257) 2257..2317 - 61 NuclAT_0 - Antitoxin
- (2257) 2257..2317 - 61 NuclAT_0 - Antitoxin
- (2257) 2257..2317 - 61 NuclAT_0 - Antitoxin
- (2257) 2257..2317 - 61 NuclAT_0 - Antitoxin
KFK82_RS28135 (2369) 2369..2521 + 153 WP_024179505.1 Hok/Gef family protein Toxin
KFK82_RS28140 (2593) 2593..2844 - 252 WP_001291962.1 hypothetical protein -
- (3237) 3237..3288 - 52 NuclAT_1 - -
- (3237) 3237..3288 - 52 NuclAT_1 - -
- (3237) 3237..3288 - 52 NuclAT_1 - -
- (3237) 3237..3288 - 52 NuclAT_1 - -
KFK82_RS28145 (4180) 4180..4356 - 177 WP_180335155.1 hypothetical protein -
KFK82_RS28150 (4749) 4749..4958 + 210 WP_000062603.1 HEAT repeat domain-containing protein -
KFK82_RS28155 (5026) 5026..5693 - 668 Protein_6 plasmid IncI1-type surface exclusion protein ExcA -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid erm(B) / blaCTX-M-104 - 1..98579 98579


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-46)


Sequences


Toxin        


Download         Length: 51 a.a.        Molecular weight: 5743.07 Da        Isoelectric Point: 8.7948

>T200520 WP_024179505.1 NZ_CP073909:2369-2521 [Klebsiella pneumoniae]
MPQRTFLMMLIVVCVTILCFVWIVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T200520 NZ_CP097884:1468041-1468448 [Escherichia coli str. K-12 substr. MG1655]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 61 bp

>AT200520 NZ_CP073909:c2317-2257 [Klebsiella pneumoniae]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Download structure file

References