Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | I | Classification (family/domain) | hok-sok/- |
Location | 2257..2521 | Replicon | plasmid pHK31_3 |
Accession | NZ_CP073909 | ||
Organism | Klebsiella pneumoniae strain HK31 |
Toxin (Protein)
Gene name | pndA | Uniprot ID | - |
Locus tag | KFK82_RS28135 | Protein ID | WP_024179505.1 |
Coordinates | 2369..2521 (+) | Length | 51 a.a. |
Antitoxin (RNA)
Gene name | pndB | ||
Locus tag | - | ||
Coordinates | 2257..2317 (-) |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
KFK82_RS28130 (869) | 869..2077 | - | 1209 | WP_064148469.1 | IncI1-type conjugal transfer protein TrbA | - |
- (2257) | 2257..2317 | - | 61 | NuclAT_0 | - | Antitoxin |
- (2257) | 2257..2317 | - | 61 | NuclAT_0 | - | Antitoxin |
- (2257) | 2257..2317 | - | 61 | NuclAT_0 | - | Antitoxin |
- (2257) | 2257..2317 | - | 61 | NuclAT_0 | - | Antitoxin |
KFK82_RS28135 (2369) | 2369..2521 | + | 153 | WP_024179505.1 | Hok/Gef family protein | Toxin |
KFK82_RS28140 (2593) | 2593..2844 | - | 252 | WP_001291962.1 | hypothetical protein | - |
- (3237) | 3237..3288 | - | 52 | NuclAT_1 | - | - |
- (3237) | 3237..3288 | - | 52 | NuclAT_1 | - | - |
- (3237) | 3237..3288 | - | 52 | NuclAT_1 | - | - |
- (3237) | 3237..3288 | - | 52 | NuclAT_1 | - | - |
KFK82_RS28145 (4180) | 4180..4356 | - | 177 | WP_180335155.1 | hypothetical protein | - |
KFK82_RS28150 (4749) | 4749..4958 | + | 210 | WP_000062603.1 | HEAT repeat domain-containing protein | - |
KFK82_RS28155 (5026) | 5026..5693 | - | 668 | Protein_6 | plasmid IncI1-type surface exclusion protein ExcA | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Conjugative plasmid | erm(B) / blaCTX-M-104 | - | 1..98579 | 98579 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5743.07 Da Isoelectric Point: 8.7948
>T200520 WP_024179505.1 NZ_CP073909:2369-2521 [Klebsiella pneumoniae]
MPQRTFLMMLIVVCVTILCFVWIVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVVCVTILCFVWIVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T200520 NZ_CP097884:1468041-1468448 [Escherichia coli str. K-12 substr. MG1655]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 61 bp
>AT200520 NZ_CP073909:c2317-2257 [Klebsiella pneumoniae]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|