Detailed information of TA system TA020040

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mqsRA (relBE)/-
• Location: 3151944..3152637
• Replicon: chromosome
• Accession: CP009789
• Organism: Escherichia coli K-12 strain ER3413

Toxin (Protein)

• Gene name: mqsR
• Uniprot ID: -
• Locus tag: ER3413_4608
• Protein ID: AIZ54280.1
• Coordinates: 3152341..3152637 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: mqsA
• Uniprot ID: -
• Locus tag: ER3413_3112
• Protein ID: AIZ52816.1
• Coordinates: 3151944..3152339 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ER3413_3110	3147808..3150066	-	2259	AIZ52814.1	DNA topoisomerase IV, subunit A	-
ER3413_3111	3150204..3151811	-	1608	AIZ52815.1	putative transporter subunit: periplasmic-binding component of ABC superfamily	-
ER3413_3112	3151944..3152339	-	396	AIZ52816.1	antitoxin for MqsR toxin; transcriptional repressor	Antitoxin
ER3413_4608	3152341..3152637	-	297	AIZ54280.1	GCU-specific mRNA interferase toxin of the MqsR-MqsA toxin-antitoxin system; biofilm/motility regulator; anti-repressor	Toxin
ER3413_3113	3152842..3153324	-	483	AIZ52817.1	transcriptional repressor for mcbR biofilm gene	-
ER3413_3114	3153377..3153769	-	393	AIZ52818.1	hypothetical protein	-
ER3413_3115	3153921..3154580	+	660	AIZ52819.1	quorum sensing DNA-binding response regulator in two-component regulatory system with QseC	-
ER3413_3116	3154577..3155926	+	1350	AIZ52820.1	quorum sensing sensory histidine kinase in two-component regulatory system with QseB	-
ER3413_4562	3155972..3156304	-	333	AIZ54230.1	inner membrane protein	-
ER3413_3117	3156623..3157204	+	582	AIZ52821.1	NADPH quinone reductase	-
ER3413_3118	3157235..3157549	+	315	AIZ52822.1	quinol monooxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase toxin MqsR (5-97)

Antitoxin

• Zinc finger, MqsA-type (3-47)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11231.96 Da
• Isoelectric Point: 8.9070

>T20040 AIZ54280.1 CP009789:c3152637-3152341 [Escherichia coli K-12]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Nucleotide

• Length: 297 bp

>T20040 CP009789:c3152637-3152341 [Escherichia coli K-12]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14703.10 Da
• Isoelectric Point: 9.2136

>AT20040 AIZ52816.1 CP009789:c3152339-3151944 [Escherichia coli K-12]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Nucleotide

• Length: 396 bp

>AT20040 CP009789:c3152339-3151944 [Escherichia coli K-12]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA