Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/-
Location 3151944..3152637 Replicon chromosome
Accession CP009789
Organism Escherichia coli K-12 strain ER3413

Toxin (Protein)


Gene name mqsR Uniprot ID -
Locus tag ER3413_4608 Protein ID AIZ54280.1
Coordinates 3152341..3152637 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID -
Locus tag ER3413_3112 Protein ID AIZ52816.1
Coordinates 3151944..3152339 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ER3413_3110 3147808..3150066 - 2259 AIZ52814.1 DNA topoisomerase IV, subunit A -
ER3413_3111 3150204..3151811 - 1608 AIZ52815.1 putative transporter subunit: periplasmic-binding component of ABC superfamily -
ER3413_3112 3151944..3152339 - 396 AIZ52816.1 antitoxin for MqsR toxin; transcriptional repressor Antitoxin
ER3413_4608 3152341..3152637 - 297 AIZ54280.1 GCU-specific mRNA interferase toxin of the MqsR-MqsA toxin-antitoxin system; biofilm/motility regulator; anti-repressor Toxin
ER3413_3113 3152842..3153324 - 483 AIZ52817.1 transcriptional repressor for mcbR biofilm gene -
ER3413_3114 3153377..3153769 - 393 AIZ52818.1 hypothetical protein -
ER3413_3115 3153921..3154580 + 660 AIZ52819.1 quorum sensing DNA-binding response regulator in two-component regulatory system with QseC -
ER3413_3116 3154577..3155926 + 1350 AIZ52820.1 quorum sensing sensory histidine kinase in two-component regulatory system with QseB -
ER3413_4562 3155972..3156304 - 333 AIZ54230.1 inner membrane protein -
ER3413_3117 3156623..3157204 + 582 AIZ52821.1 NADPH quinone reductase -
ER3413_3118 3157235..3157549 + 315 AIZ52822.1 quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T20040 AIZ54280.1 CP009789:c3152637-3152341 [Escherichia coli K-12]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T20040 CP009789:c3152637-3152341 [Escherichia coli K-12]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT20040 AIZ52816.1 CP009789:c3152339-3151944 [Escherichia coli K-12]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT20040 CP009789:c3152339-3151944 [Escherichia coli K-12]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References