Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/-
Location 2079357..2079859 Replicon chromosome
Accession CP009789
Organism Escherichia coli K-12 strain ER3413

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag ER3413_4578 Protein ID AIZ54247.1
Coordinates 2079357..2079611 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag ER3413_2081 Protein ID AIZ51828.1
Coordinates 2079608..2079859 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ER3413_2076 2074372..2074599 - 228 AIZ51823.1 hypothetical protein -
ER3413_2077 2074613..2075671 - 1059 AIZ51824.1 inner membrane protein, UPF0394 family -
ER3413_2078 2075850..2077208 - 1359 AIZ51825.1 putrescine importer, low affinity -
ER3413_4523 2077198..2077260 - 63 AIZ54187.1 hypothetical protein -
ER3413_2079 2077475..2078404 - 930 AIZ51826.1 putative DNA-binding transcriptional regulator -
ER3413_2080 2078450..2079274 - 825 AIZ51827.1 putative epimerase, with NAD(P)-binding Rossmann-fold domain -
ER3413_4578 2079357..2079611 - 255 AIZ54247.1 toxin of the YoeB-YefM toxin-antitoxin system Toxin
ER3413_2081 2079608..2079859 - 252 AIZ51828.1 antitoxin of the YoeB-YefM toxin-antitoxin system Antitoxin
ER3413_4619 2080142..2080192 + 51 AIZ54292.1 his operon leader peptide -
ER3413_2082 2080338..2081201 + 864 AIZ51829.1 ATP phosphoribosyltransferase -
ER3413_2083 2081207..2082511 + 1305 AIZ51830.1 bifunctional histidinal dehydrogenase/ histidinol dehydrogenase -
ER3413_2084 2082508..2083578 + 1071 AIZ51831.1 histidinol-phosphate aminotransferase -
ER3413_2085 2083578..2084645 + 1068 AIZ51832.1 fused histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T20036 AIZ54247.1 CP009789:c2079611-2079357 [Escherichia coli K-12]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T20036 CP009789:c2079611-2079357 [Escherichia coli K-12]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT20036 AIZ51828.1 CP009789:c2079859-2079608 [Escherichia coli K-12]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT20036 CP009789:c2079859-2079608 [Escherichia coli K-12]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References