Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 334546..335135 Replicon chromosome
Accession NZ_CP073820
Organism Xanthomonas oryzae strain PXO99A-gx

Toxin (Protein)


Gene name graT Uniprot ID G7TIR7
Locus tag KFK26_RS01495 Protein ID WP_012443754.1
Coordinates 334546..334827 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KFK26_RS01500 Protein ID WP_011260746.1
Coordinates 334845..335135 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFK26_RS01490 (KFK26_01495) 332199..334451 + 2253 WP_012443753.1 exodeoxyribonuclease V subunit alpha -
KFK26_RS01495 (KFK26_01500) 334546..334827 + 282 WP_012443754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
KFK26_RS01500 (KFK26_01505) 334845..335135 + 291 WP_011260746.1 HigA family addiction module antitoxin Antitoxin
KFK26_RS01505 (KFK26_01510) 336064..337458 + 1395 WP_027703652.1 type III secretion system effector XopQ -
KFK26_RS01510 337561..337748 - 188 Protein_296 hypothetical protein -
KFK26_RS01515 (KFK26_01515) 337908..338240 - 333 WP_011260743.1 hypothetical protein -
KFK26_RS01520 (KFK26_01520) 338495..338800 + 306 WP_224229802.1 hypothetical protein -
KFK26_RS01525 (KFK26_01525) 338950..339372 + 423 WP_033013301.1 PAAR domain-containing protein -
KFK26_RS01530 (KFK26_01530) 339375..339851 + 477 WP_011260741.1 DUF4123 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-68)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11066.83 Da        Isoelectric Point: 10.5318

>T200337 WP_012443754.1 NZ_CP073820:334546-334827 [Xanthomonas oryzae]
VIRSFIDKDAEKIWLGERSRRLPADIQLVARRKLRMLNAAAHLDDLRIPPANRLEALKGQRRGQYSIRINDQWRICFRWM
EGDVVQVEIVDYH

Download         Length: 282 bp

>T200337 NZ_CP097831:c3386982-3386827 [Shigella flexneri]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10420.07 Da        Isoelectric Point: 7.2040

>AT200337 WP_011260746.1 NZ_CP073820:334845-335135 [Xanthomonas oryzae]
MTVLPNIHPGDILLEEFLEPLGISQNALARATGVPPRRINEIVLGKRGITADTAVRLAAALGTSERFWLGLQADYELEQA
HRALGDLPARIKRLAA

Download         Length: 291 bp

>AT200337 NZ_CP097831:3386994-3387052 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATTTGTGAGACATAGATTGGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K0GFW5

Antitoxin

Source ID Structure

References