Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1336831..1337353 Replicon chromosome
Accession NZ_CP073819
Organism Macrococcus epidermidis strain Epi3002-OL

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KFV12_RS07020 Protein ID WP_086042495.1
Coordinates 1336831..1337103 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KFV12_RS07025 Protein ID WP_254256434.1
Coordinates 1337096..1337353 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV12_RS06985 (KFV12_07015) 1332139..1332909 + 771 WP_254256427.1 nuclear transport factor 2 family protein -
KFV12_RS06990 (KFV12_07020) 1332967..1333404 + 438 WP_254256428.1 Rrf2 family transcriptional regulator -
KFV12_RS06995 (KFV12_07025) 1333504..1334307 + 804 WP_254256429.1 protein-ADP-ribose hydrolase -
KFV12_RS07000 (KFV12_07030) 1334291..1335277 + 987 WP_254256430.1 Sir2 silent information regulator family NAD-dependent deacetylase -
KFV12_RS07005 (KFV12_07035) 1335554..1336039 + 486 WP_254256431.1 NUDIX domain-containing protein -
KFV12_RS07010 (KFV12_07040) 1336045..1336467 + 423 WP_254256432.1 hypothetical protein -
KFV12_RS07015 (KFV12_07045) 1336499..1336813 + 315 WP_254256433.1 hypothetical protein -
KFV12_RS07020 (KFV12_07050) 1336831..1337103 - 273 WP_086042495.1 Txe/YoeB family addiction module toxin Toxin
KFV12_RS07025 (KFV12_07055) 1337096..1337353 - 258 WP_254256434.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KFV12_RS07030 (KFV12_07060) 1337484..1338656 - 1173 WP_254256435.1 MFS transporter -
KFV12_RS07035 (KFV12_07065) 1338849..1339205 - 357 WP_254256436.1 cupin -
KFV12_RS07040 (KFV12_07070) 1339360..1339854 + 495 WP_254256437.1 isochorismatase family cysteine hydrolase -
KFV12_RS07045 (KFV12_07075) 1340176..1341789 + 1614 WP_254256438.1 ABC-F type ribosomal protection protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10694.45 Da        Isoelectric Point: 9.7524

>T200334 WP_086042495.1 NZ_CP073819:c1337103-1336831 [Macrococcus epidermidis]
MPKKKILFYSSGFEDYTYWQTNDKTVLKKINKLIKSIMIDGANEGIGKPEKLLGNYTGCYSRRITHEHRLVYKIEDDSIC
ILQCRFHYKR

Download         Length: 273 bp

>T200334 NZ_CP097831:2729323-2729478 [Shigella flexneri]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTTATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9718.81 Da        Isoelectric Point: 4.2805

>AT200334 WP_254256434.1 NZ_CP073819:c1337353-1337096 [Macrococcus epidermidis]
MKVTTYSNARSNFRKIIDIVNEDCEPYTITTNTHNAVILSEQDYNSMIETLYLHSTPANAERLQKAIDESIDKNNLLQVE
IDLDA

Download         Length: 258 bp

>AT200334 NZ_CP097831:c2729311-2729253 [Shigella flexneri]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References