200329

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1168352..1168863 Replicon chromosome
Accession NZ_CP073808
Organism Macrococcus canis strain IMD0709

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KFV10_RS05935 Protein ID WP_236365518.1
Coordinates 1168603..1168863 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KFV10_RS05930 Protein ID WP_254253287.1
Coordinates 1168352..1168603 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV10_RS05895 (KFV10_05885) 1163733..1164236 - 504 WP_254253283.1 peptide-methionine (S)-S-oxide reductase MsrA -
KFV10_RS05900 (KFV10_05890) 1164359..1165300 + 942 WP_254253284.1 LCP family protein -
KFV10_RS05905 (KFV10_05895) 1165338..1165526 - 189 WP_086042483.1 2-hydroxymuconate tautomerase -
KFV10_RS05910 (KFV10_05900) 1165575..1166579 - 1005 WP_236365517.1 cation diffusion facilitator family transporter -
KFV10_RS05915 (KFV10_05905) 1166741..1167127 + 387 WP_254253285.1 sporulation protein -
KFV10_RS05920 (KFV10_05910) 1167190..1167705 - 516 WP_086042487.1 DUF402 domain-containing protein -
KFV10_RS05925 (KFV10_05915) 1167798..1168256 + 459 WP_254253286.1 NUDIX domain-containing protein -
KFV10_RS05930 (KFV10_05920) 1168352..1168603 + 252 WP_254253287.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KFV10_RS05935 (KFV10_05925) 1168603..1168863 + 261 WP_236365518.1 Txe/YoeB family addiction module toxin Toxin
KFV10_RS05940 (KFV10_05930) 1168864..1169313 - 450 WP_086042491.1 GNAT family N-acetyltransferase -
KFV10_RS05945 (KFV10_05935) 1169531..1170421 + 891 WP_254253288.1 phosphotransferase -
KFV10_RS05950 (KFV10_05940) 1170545..1171030 + 486 WP_254253289.1 NUDIX domain-containing protein -
KFV10_RS05955 (KFV10_05945) 1171036..1171797 + 762 WP_254253290.1 hypothetical protein -
KFV10_RS05960 (KFV10_05950) 1171820..1172092 - 273 WP_254253291.1 Txe/YoeB family addiction module toxin -
KFV10_RS05965 (KFV10_05955) 1172085..1172342 - 258 WP_086042496.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
KFV10_RS05970 (KFV10_05960) 1172631..1172855 + 225 WP_086042497.1 DUF6290 family protein -
KFV10_RS05975 (KFV10_05965) 1172882..1173118 + 237 WP_254253292.1 type II toxin-antitoxin system RelE/ParE family toxin -
KFV10_RS05980 (KFV10_05970) 1173229..1173597 + 369 WP_236365523.1 GntR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(3-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-59)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10283.93 Da        Isoelectric Point: 10.1614

>T200329 WP_236365518.1 NZ_CP073808:1168603-1168863 [Macrococcus canis]
MYKIVMKSSVKKDLKKIKNTHLEPNFLKIINQLKENPYNNNHSFEKLIPPIKGFYSRRINVQHRVVYTVNDEDKIVTIYS
AYGHYE

Download         Length: 261 bp

>T200329 NZ_CP097831:1156002-1156109 [Shigella flexneri]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9576.62 Da        Isoelectric Point: 4.0373

>AT200329 WP_254253287.1 NZ_CP073808:1168352-1168603 [Macrococcus canis]
MNTYTPTSARKDFFNIIKSVNEDSKEIYIAPTKVGEKGAVLVGEDDWNAIQETLFLLEKGIAYQIEQRKDEEEIDFDSTW
DNI

Download         Length: 252 bp

>AT200329 NZ_CP097831:c1155945-1155890 [Shigella flexneri]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References