Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1074569..1075091 Replicon chromosome
Accession NZ_CP073801
Organism Macrococcus caseolyticus strain 19Msa198

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KFV06_RS05360 Protein ID WP_101030752.1
Coordinates 1074569..1074841 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KFV06_RS05365 Protein ID WP_086038671.1
Coordinates 1074834..1075091 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV06_RS05330 (KFV06_05330) 1070601..1070987 + 387 WP_157819678.1 sporulation protein -
KFV06_RS05335 (KFV06_05335) 1071088..1071537 - 450 WP_101030762.1 GNAT family N-acetyltransferase -
KFV06_RS05340 (KFV06_05340) 1071620..1072360 + 741 WP_101030760.1 hypothetical protein -
KFV06_RS05345 (KFV06_05345) 1072370..1073260 + 891 WP_012656930.1 phosphotransferase -
KFV06_RS05350 (KFV06_05350) 1073292..1073777 + 486 WP_101030758.1 NUDIX domain-containing protein -
KFV06_RS05355 (KFV06_05355) 1073783..1074541 + 759 WP_101030755.1 hypothetical protein -
KFV06_RS05360 (KFV06_05360) 1074569..1074841 - 273 WP_101030752.1 Txe/YoeB family addiction module toxin Toxin
KFV06_RS05365 (KFV06_05365) 1074834..1075091 - 258 WP_086038671.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KFV06_RS05370 (KFV06_05370) 1075222..1076394 - 1173 WP_101030749.1 MFS transporter -
KFV06_RS05375 (KFV06_05375) 1076586..1076942 - 357 WP_101030747.1 cupin -
KFV06_RS05380 (KFV06_05380) 1077097..1077591 + 495 WP_157819679.1 isochorismatase family protein -
KFV06_RS05385 (KFV06_05385) 1078159..1079118 + 960 WP_101141862.1 IS30 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1078159..1079118 959


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(10-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10670.39 Da        Isoelectric Point: 9.7524

>T200321 WP_101030752.1 NZ_CP073801:c1074841-1074569 [Macrococcus caseolyticus]
MSKKKILFYSSGFEDYTYWQTNDKTVLKKINKLIKSIMIDGANEGVGKPEKLLGNYTGCYSRRITHEHRLVYKIEDDSIC
ILQCRFHYKR

Download         Length: 273 bp

>T200321 NZ_CP097828:4177068-4177355 [Shigella flexneri]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9738.84 Da        Isoelectric Point: 4.0936

>AT200321 WP_086038671.1 NZ_CP073801:c1075091-1074834 [Macrococcus caseolyticus]
MKVTTYSNARSNFRKIIDIVNEDCEPYTITTNTHNAVILSEQDYNSMIETLYLQSTPANAERLQKAIDESIDKNNLLEVE
IDLDV

Download         Length: 258 bp

>AT200321 NZ_CP097828:4176829-4177068 [Shigella flexneri]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References