Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-RelB
Location 1162232..1162754 Replicon chromosome
Accession NZ_CP073798
Organism Macrococcus canis strain KM2258

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KFV04_RS05755 Protein ID WP_254254483.1
Coordinates 1162232..1162504 (-) Length 91 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KFV04_RS05760 Protein ID WP_086042496.1
Coordinates 1162497..1162754 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV04_RS05715 (KFV04_05695) 1157868..1158371 - 504 WP_086042481.1 peptide-methionine (S)-S-oxide reductase MsrA -
KFV04_RS05720 (KFV04_05700) 1158494..1159435 + 942 WP_254254477.1 LCP family protein -
KFV04_RS05725 (KFV04_05705) 1159473..1159661 - 189 WP_086042483.1 2-hydroxymuconate tautomerase -
KFV04_RS05730 (KFV04_05710) 1159710..1160714 - 1005 WP_254254478.1 cation diffusion facilitator family transporter -
KFV04_RS05735 (KFV04_05715) 1160876..1161262 + 387 WP_254254479.1 sporulation protein -
KFV04_RS05740 (KFV04_05720) 1161337..1161588 + 252 WP_254254480.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
KFV04_RS05745 (KFV04_05725) 1161588..1161800 + 213 WP_254254481.1 type II toxin-antitoxin system YoeB family toxin -
KFV04_RS05750 (KFV04_05730) 1161784..1162209 + 426 WP_254254482.1 hypothetical protein -
KFV04_RS05755 (KFV04_05735) 1162232..1162504 - 273 WP_254254483.1 Txe/YoeB family addiction module toxin Toxin
KFV04_RS05760 (KFV04_05740) 1162497..1162754 - 258 WP_086042496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KFV04_RS05765 (KFV04_05745) 1163043..1163267 + 225 WP_236365521.1 DUF6290 family protein -
KFV04_RS05770 (KFV04_05750) 1163294..1163530 + 237 WP_236365522.1 type II toxin-antitoxin system RelE/ParE family toxin -
KFV04_RS05775 (KFV04_05755) 1163641..1164009 + 369 WP_254254484.1 GntR family transcriptional regulator -
KFV04_RS05780 (KFV04_05760) 1164009..1165109 + 1101 WP_254254485.1 DUF1648 domain-containing protein -
KFV04_RS05785 (KFV04_05765) 1165551..1166813 + 1263 WP_236366941.1 Y-family DNA polymerase -
KFV04_RS05790 (KFV04_05770) 1166966..1167154 + 189 WP_254254486.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 91 a.a.        Molecular weight: 10644.44 Da        Isoelectric Point: 10.0864

>T200315 WP_254254483.1 NZ_CP073798:c1162504-1162232 [Macrococcus canis]
MPKKKILFYSSGFEDYTYWQTNDKTVLKKINKLIKSIMIDGANKGIGKPEKLLGNYTGCNSRRITHEHRLVYKIEDDSIC
ILQCRFHYKR

Download         Length: 273 bp

>T200315 NZ_CP097828:c2914397-2913999 [Shigella flexneri]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAGCCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGAAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9697.75 Da        Isoelectric Point: 4.1540

>AT200315 WP_086042496.1 NZ_CP073798:c1162754-1162497 [Macrococcus canis]
MKVTTYSNARSNFRKIIDIVNEDCEPYTITTNTHNAVILSEQDYNSMIETLYLQSTPANAERLQKAIDESTDKNNLLQVE
IDLDA

Download         Length: 258 bp

>AT200315 NZ_CP097828:c2914693-2914400 [Shigella flexneri]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
AGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTTCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
AAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References