Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1161337..1161800 Replicon chromosome
Accession NZ_CP073798
Organism Macrococcus canis strain KM2258

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag KFV04_RS05745 Protein ID WP_254254481.1
Coordinates 1161588..1161800 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag KFV04_RS05740 Protein ID WP_254254480.1
Coordinates 1161337..1161588 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFV04_RS05715 (KFV04_05695) 1157868..1158371 - 504 WP_086042481.1 peptide-methionine (S)-S-oxide reductase MsrA -
KFV04_RS05720 (KFV04_05700) 1158494..1159435 + 942 WP_254254477.1 LCP family protein -
KFV04_RS05725 (KFV04_05705) 1159473..1159661 - 189 WP_086042483.1 2-hydroxymuconate tautomerase -
KFV04_RS05730 (KFV04_05710) 1159710..1160714 - 1005 WP_254254478.1 cation diffusion facilitator family transporter -
KFV04_RS05735 (KFV04_05715) 1160876..1161262 + 387 WP_254254479.1 sporulation protein -
KFV04_RS05740 (KFV04_05720) 1161337..1161588 + 252 WP_254254480.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
KFV04_RS05745 (KFV04_05725) 1161588..1161800 + 213 WP_254254481.1 type II toxin-antitoxin system YoeB family toxin Toxin
KFV04_RS05750 (KFV04_05730) 1161784..1162209 + 426 WP_254254482.1 hypothetical protein -
KFV04_RS05755 (KFV04_05735) 1162232..1162504 - 273 WP_254254483.1 Txe/YoeB family addiction module toxin -
KFV04_RS05760 (KFV04_05740) 1162497..1162754 - 258 WP_086042496.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
KFV04_RS05765 (KFV04_05745) 1163043..1163267 + 225 WP_236365521.1 DUF6290 family protein -
KFV04_RS05770 (KFV04_05750) 1163294..1163530 + 237 WP_236365522.1 type II toxin-antitoxin system RelE/ParE family toxin -
KFV04_RS05775 (KFV04_05755) 1163641..1164009 + 369 WP_254254484.1 GntR family transcriptional regulator -
KFV04_RS05780 (KFV04_05760) 1164009..1165109 + 1101 WP_254254485.1 DUF1648 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-59)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8364.81 Da        Isoelectric Point: 10.7107

>T200314 WP_254254481.1 NZ_CP073798:1161588-1161800 [Macrococcus canis]
MYKIVMKSSVKKDLKKIKNTHFLKIIKLLNENPYNNNHSFEKLISPIKGFNSRRINVQHRVVYSAYGHYE

Download         Length: 213 bp

>T200314 NZ_CP097828:c1717315-1717208 [Shigella flexneri]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9587.64 Da        Isoelectric Point: 4.0373

>AT200314 WP_254254480.1 NZ_CP073798:1161337-1161588 [Macrococcus canis]
MNTYTPANARKDFFNIIKSVNEDSKEIYIAPTKIGEKGAVLVGEDDWNAIQETLFLLEKGIAYQIEQRKDEEEIDFDSTW
DNI

Download         Length: 252 bp

>AT200314 NZ_CP097828:1717364-1717430 [Shigella flexneri]
GTCTAGGTTCAAGATTAGCCCCCGTTATGTTGTCAGGTACATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References