200313

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 10430465..10431144 Replicon chromosome
Accession NZ_CP073797
Organism Dactylosporangium matsuzakiense strain NRRL B-16293

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag Dmats_RS47700 Protein ID WP_261962034.1
Coordinates 10430465..10430830 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Dmats_RS47705 Protein ID WP_261962035.1
Coordinates 10430827..10431144 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Dmats_RS47660 (Dmats_47430) 10426566..10427096 + 531 WP_261962031.1 isopentenyl-diphosphate Delta-isomerase -
Dmats_RS47665 (Dmats_47435) 10427093..10427971 + 879 WP_261966267.1 MerR family transcriptional regulator -
Dmats_RS47670 (Dmats_47440) 10428140..10429009 + 870 WP_261966268.1 polysaccharide deacetylase family protein -
Dmats_RS47690 (Dmats_47460) 10429653..10429856 + 204 WP_261962032.1 hypothetical protein -
Dmats_RS47695 (Dmats_47465) 10429849..10430118 + 270 WP_261962033.1 hypothetical protein -
Dmats_RS47700 (Dmats_47470) 10430465..10430830 + 366 WP_261962034.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Dmats_RS47705 (Dmats_47475) 10430827..10431144 + 318 WP_261962035.1 helix-turn-helix transcriptional regulator Antitoxin
Dmats_RS47710 (Dmats_47480) 10431862..10432401 - 540 WP_223100062.1 bacterial proteasome activator family protein -
Dmats_RS47715 (Dmats_47485) 10432522..10433340 + 819 WP_261962036.1 alpha/beta fold hydrolase -
Dmats_RS47720 (Dmats_47490) 10433450..10434661 + 1212 WP_223100066.1 ABC transporter substrate-binding protein -
Dmats_RS47725 (Dmats_47495) 10434669..10435061 - 393 WP_261962037.1 hypothetical protein -
Dmats_RS47730 (Dmats_47500) 10435111..10435518 - 408 WP_246655903.1 hotdog fold thioesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(17-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13753.73 Da        Isoelectric Point: 4.9473

>T200313 WP_261962034.1 NZ_CP073797:10430465-10430830 [Dactylosporangium matsuzakiense]
VTTPEWGIYVVDEVRAWIYSLEPTAKARVVLAIDALAENGPALGRPLVDTITHSSLANLKELRPGTMRILFVFDPWRSSI
LLVAGDKAGQWEAWYREALPLAEQRYEVYLKERAKEEGDQR

Download         Length: 366 bp

>T200313 NZ_CP097828:c1716832-1716725 [Shigella flexneri]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11368.78 Da        Isoelectric Point: 6.4719

>AT200313 WP_261962035.1 NZ_CP073797:10430827-10431144 [Dactylosporangium matsuzakiense]
MSSYVRWSDIRAELVEQAGGEEAVAAGKQELLAEVTGHRLAEARRSRGLTQQQVADRMGVTKGRVSQIEQGKVSGQEVLA
RYAVALGGRLHQAIYFEDGDITAIA

Download         Length: 318 bp

>AT200313 NZ_CP097828:1716889-1716944 [Shigella flexneri]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References