Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 11332402..11333081 Replicon chromosome
Accession NZ_CP073767
Organism Dactylosporangium aurantiacum strain NRRL B-8018

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag Daura_RS50875 Protein ID WP_033360641.1
Coordinates 11332402..11332767 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Daura_RS50880 Protein ID WP_033360574.1
Coordinates 11332764..11333081 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Daura_RS50840 (Daura_50570) 11327429..11328925 + 1497 WP_033360572.1 phytoene desaturase family protein -
Daura_RS50845 (Daura_50575) 11328964..11329497 + 534 WP_033360639.1 isopentenyl-diphosphate Delta-isomerase -
Daura_RS50850 (Daura_50580) 11329494..11330408 + 915 WP_033360573.1 MerR family transcriptional regulator -
Daura_RS50855 (Daura_50585) 11330557..11331438 + 882 WP_052387032.1 polysaccharide deacetylase family protein -
Daura_RS50875 (Daura_50605) 11332402..11332767 + 366 WP_033360641.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Daura_RS50880 (Daura_50610) 11332764..11333081 + 318 WP_033360574.1 helix-turn-helix transcriptional regulator Antitoxin
Daura_RS50885 (Daura_50615) 11333454..11334011 + 558 WP_081970934.1 Uma2 family endonuclease -
Daura_RS50890 (Daura_50620) 11334134..11335171 - 1038 WP_033360575.1 hypothetical protein -
Daura_RS50895 (Daura_50625) 11335168..11335497 - 330 WP_211273613.1 PadR family transcriptional regulator -
Daura_RS50900 (Daura_50630) 11335787..11336443 + 657 WP_052387033.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(17-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13598.49 Da        Isoelectric Point: 4.9062

>T200177 WP_033360641.1 NZ_CP073767:11332402-11332767 [Dactylosporangium aurantiacum]
VATSEWGIYVVNEVRTWIFSLEPAAKARVVQAIDALAESGPGLGRPLVDTITHSSLANLKELRPGTMRILFVFDPWRSSI
LLVAGDKAAQWEGWYREAIPLAEQRYEIYLKERAQEEGGQQ

Download         Length: 366 bp

>T200177 NZ_CP097719:3732103-3732321 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11310.70 Da        Isoelectric Point: 6.4709

>AT200177 WP_033360574.1 NZ_CP073767:11332764-11333081 [Dactylosporangium aurantiacum]
MSSYVRWSDIRGELVEQAGGEEAVAAGKQELLAEVTGHRLAEARRGRGLTQQQVADRMGVTKGRVSQIEQGKVSGQEVLA
RYAVALGGRLHQAIYFDDGDITAIA

Download         Length: 318 bp

>AT200177 NZ_CP097719:3731703-3732077 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCGCAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References