Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 10048543..10049213 Replicon chromosome
Accession NZ_CP073767
Organism Dactylosporangium aurantiacum strain NRRL B-8018

Toxin (Protein)


Gene name HigB2 Uniprot ID -
Locus tag Daura_RS44825 Protein ID WP_245635672.1
Coordinates 10048878..10049213 (-) Length 112 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Daura_RS44820 Protein ID WP_033364160.1
Coordinates 10048543..10048878 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Daura_RS44805 (Daura_44555) 10043904..10044275 + 372 WP_033364039.1 hypothetical protein -
Daura_RS44810 (Daura_44560) 10044324..10046984 - 2661 WP_260709906.1 pyruvate, phosphate dikinase -
Daura_RS44815 (Daura_44565) 10047378..10048439 + 1062 WP_245635671.1 tRNA dihydrouridine synthase DusB -
Daura_RS44820 (Daura_44570) 10048543..10048878 - 336 WP_033364160.1 XRE family transcriptional regulator Antitoxin
Daura_RS44825 (Daura_44575) 10048878..10049213 - 336 WP_245635672.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Daura_RS44830 (Daura_44580) 10049680..10050585 - 906 WP_033364042.1 NAD(P)H-binding protein -
Daura_RS44835 (Daura_44585) 10050647..10051429 - 783 WP_052387954.1 metallophosphoesterase family protein -
Daura_RS44840 (Daura_44590) 10051426..10052223 - 798 WP_033364043.1 SAM-dependent methyltransferase -
Daura_RS44845 (Daura_44595) 10052295..10053332 - 1038 WP_245635673.1 CU044_5270 family protein -
Daura_RS44850 (Daura_44600) 10053338..10053940 - 603 WP_052387955.1 RNA polymerase sigma factor -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(3-97)

Antitoxin

HigA2-like, helix-turn-helix domain

(17-100)


Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 12115.76 Da        Isoelectric Point: 8.6239

>T200174 WP_245635672.1 NZ_CP073767:c10049213-10048878 [Dactylosporangium aurantiacum]
MHDLRHSDRRTLVLISAAVDALAAEGPALGRPLVDTVRGSKLANLKESRPGSAGSSEVRLLFVFDPVRQAVLLVGGDKAG
NWQGWYRTAIPIAETAYAEHLRRLQEKDGEQ

Download         Length: 336 bp

>T200174 NZ_CP097719:3068051-3068545 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGATCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12377.03 Da        Isoelectric Point: 5.2237

>AT200174 WP_033364160.1 NZ_CP073767:c10048878-10048543 [Dactylosporangium aurantiacum]
MDHLKDPQAIAWDDMKAELGFTDAERDEIRMGAQELIAQARAYRLAEVRRRQHATQTDIAKVMGVTQARVSRIEKGEISR
SEVDTLAAYVQALGGKLKIIADFGDESYVLG

Download         Length: 336 bp

>AT200174 NZ_CP097719:3067761-3068054 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAGCCAGGCGCGAATCTTTAAACTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTATCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References