Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2385376..2385989 Replicon chromosome
Accession NZ_CP073764
Organism Methylovirgula sp. HY1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MHY1_RS11145 Protein ID WP_219319873.1
Coordinates 2385693..2385989 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MHY1_RS11140 Protein ID WP_219319872.1
Coordinates 2385376..2385684 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MHY1_RS11105 2380486..2380650 + 165 WP_219319866.1 hypothetical protein -
MHY1_RS11110 (MHY1_02272) 2381410..2382234 - 825 WP_219319867.1 IS5 family transposase -
MHY1_RS11115 (MHY1_02273) 2382314..2382541 + 228 WP_219319868.1 hypothetical protein -
MHY1_RS11120 (MHY1_02274) 2382731..2383261 - 531 WP_219319869.1 DUF2244 domain-containing protein -
MHY1_RS11125 (MHY1_02275) 2383310..2384071 + 762 WP_219319870.1 endonuclease III -
MHY1_RS11130 (MHY1_02276) 2384104..2385162 + 1059 WP_255564876.1 Holliday junction branch migration DNA helicase RuvB -
MHY1_RS11140 (MHY1_02278) 2385376..2385684 - 309 WP_219319872.1 HigA family addiction module antitoxin Antitoxin
MHY1_RS11145 (MHY1_02279) 2385693..2385989 - 297 WP_219319873.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MHY1_RS11150 (MHY1_02281) 2386319..2387791 - 1473 WP_219319874.1 methyl-accepting chemotaxis protein -
MHY1_RS11155 (MHY1_02282) 2388002..2388358 - 357 WP_219319875.1 hypothetical protein -
MHY1_RS11160 (MHY1_02283) 2388513..2389706 + 1194 WP_219319876.1 FIST N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2381410..2382234 824


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-97)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(5-84)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11612.01 Da        Isoelectric Point: 6.8805

>T200164 WP_219319873.1 NZ_CP073764:c2385989-2385693 [Methylovirgula sp. HY1]
MIVSFRDEWLRAFFVEDTPSRHIPSDLESRLFRKLQMIDDATTDQDLRVPLSNHFEKLRGSLAGFHSIRVNSRWRLVFQW
NGSRGEADGVYLDDHSYR

Download         Length: 297 bp

>T200164 NZ_CP097719:c844332-843958 [Escherichia coli]
ATGAAAACATTACCCGATACACACGTACGGGAGGCATCGAGCTGCCCGTCTCCCGTCACCATCTGGCAGACTCTGCTCTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAATTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11461.29 Da        Isoelectric Point: 10.5834

>AT200164 WP_219319872.1 NZ_CP073764:c2385684-2385376 [Methylovirgula sp. HY1]
MLTTKRKPATIGEILIEEFMQPMGLTQAALAEAMGVQRKHVNELCNNRRNVTAATALILARVFGNSPDFWLNVQRRSDLW
EAMNSPKERERIERAKPLGAAA

Download         Length: 309 bp

>AT200164 NZ_CP097719:c844790-844422 [Escherichia coli]
GTGTCAGACGCACTCTCCGGGACAATGCTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGTCTGACCTGCAAAGCTGACACTCTCGGTAGCGG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References