Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2153607..2154371 Replicon chromosome
Accession NZ_CP073745
Organism Bacterioplanoides sp. SCSIO 12839

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag KFF03_RS09930 Protein ID WP_255856734.1
Coordinates 2154060..2154371 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag KFF03_RS09925 Protein ID WP_255856733.1
Coordinates 2153607..2154047 (-) Length 147 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KFF03_RS09910 (KFF03_09860) 2151225..2151644 - 420 WP_255856731.1 hypothetical protein -
KFF03_RS09915 (KFF03_09865) 2151650..2152918 - 1269 WP_255856732.1 AAA family ATPase -
KFF03_RS09920 2153320..2153433 + 114 Protein_1933 damage-inducible protein J -
KFF03_RS09925 (KFF03_09875) 2153607..2154047 - 441 WP_255856733.1 transcriptional regulator Antitoxin
KFF03_RS09930 (KFF03_09880) 2154060..2154371 - 312 WP_255856734.1 type II toxin-antitoxin system HigB family toxin Toxin
KFF03_RS09935 (KFF03_09885) 2154443..2155501 - 1059 WP_255856735.1 asparaginase domain-containing protein -
KFF03_RS09940 (KFF03_09890) 2155501..2155719 - 219 WP_255856736.1 hypothetical protein -
KFF03_RS09945 (KFF03_09895) 2155835..2156170 + 336 WP_255856737.1 zinc ribbon domain-containing protein YjdM -
KFF03_RS09950 (KFF03_09900) 2156280..2156645 + 366 WP_255856738.1 STAS/SEC14 domain-containing protein -
KFF03_RS09955 (KFF03_09905) 2156664..2156936 - 273 WP_255856739.1 hypothetical protein -
KFF03_RS09960 (KFF03_09910) 2157064..2157924 + 861 WP_255856740.1 PA4780 family RIO1-like protein kinase -
KFF03_RS09965 (KFF03_09915) 2158047..2158241 + 195 WP_255856741.1 type II toxin-antitoxin system VapB family antitoxin -
KFF03_RS09970 (KFF03_09920) 2158238..2158639 + 402 WP_255856742.1 PIN domain nuclease -
KFF03_RS09975 (KFF03_09925) 2158656..2159042 - 387 WP_255856743.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(20-93)

Antitoxin

Antitoxin HigA

(3-140)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12162.04 Da        Isoelectric Point: 10.1006

>T200146 WP_255856734.1 NZ_CP073745:c2154371-2154060 [Bacterioplanoides sp. SCSIO 12839]
MHLISRKPFNDAVKKYPNQASAIEGIYKTLRNGNFHDPAALRSVFPSLDNFKYKDKWWVIDIGGNKLRLIAFIEFRDNRM
YVKHIVSHAEYDKLCRKYAKEAE

Download         Length: 312 bp

>T200146 NZ_CP097716:3941086-3941742 [Escherichia coli]
ATGGCTTATGATTACAGCGCCAGCCTCAACCCGCAAAAGGCTCTGATCTGGCGTATCGTCCATCGGGACAATATCCCGTG
GATTCTGGATAACGGGCTGCACTGCGGCAACAGTCTGGTGCAGGCGGAAAACTGGATCAATATCGGCAACCCGGAGCTGA
TCGGCAAGCGTGCCGGGCATCCGGTACCTGTCGGAACGGGCGGGACACTGCATGACTATGTGCCGTTTTATTTTACCCCC
TTCTCGCCAATGCTGATGAACATCCACAGCGGGCGCGGCGGCATTAAGCAACGCCCCAATGAGGAGATCGTTATTCTGGT
CAGCAACTTGCGAAACGTGGCAGCACACGACGTACCCTTCGTGTTTACCGACAGCCATGCTTACTATAACTGGACCAACT
ACTACACCAGTCTGGATAGTCTGGACCAGATCGACTGGCCCATTTTGCAGGCACGGGACTTTCGCCGCGATCCAGACGAT
CCGGCTAAATTTGAACGCTATCAGGCAGAGGCGCTAATCTGGCAACACTGCCCGATCTCTCTGCTGGATGGGATAATTTG
TTACAGCGAAGAGGTCAGGTTACAATTAGAACAATGGCTGTTTCAGCGTAATCTAACAATGTCCGTTCACACACGGGCTG
GATGGTACTTCTCATGA

Antitoxin


Download         Length: 147 a.a.        Molecular weight: 16640.74 Da        Isoelectric Point: 4.2770

>AT200146 WP_255856733.1 NZ_CP073745:c2154047-2153607 [Bacterioplanoides sp. SCSIO 12839]
MSFSSIKTMASDLFNQAGFVSKIHNDDEYQQALALMDELIEEYDNYVPLIEVLAASIEKWENESEEFAEFNQRINALDDG
VAVLRTLMDQYQLKADDLKNEIGSKSLVSMILNGSRKLTRDHIQALSERFHVSPAVFFNMESVRAV

Download         Length: 441 bp

>AT200146 NZ_CP097716:3941739-3942806 [Escherichia coli]
ATGATCACATATACACAAGGCAATTTACTGGACGCACCGGTGGAAGCTCTGGTGAATACGGTTAATACCGTCGGTGTCAT
GGGGAAAGGCATCGCGTTGATGTTTAAAGAGCGCTTCCCCGAAAATATGAAAGTCTATGCCCTCGCCTGCAAACAAAAGC
AGGTGATCACCGGCAAAATGTTCATTACCGAAACCGGGGAACTGATGGGACCGCGCTGGATTGTTAATTTTCCGACCAAA
CAGCACTGGCGCGCCGATTCCCGCATGGAGTGGATTGAAGATGGCTTGCAGGACTTACGCCGCTTTTTGATTGAAGAGAA
CGTGCAGTCCATCGCCATTCCACCACTGGGCGCAGGCAACGGTGGTTTGAACTGGCCGGACGTTCGGGCGCAGATTGAAT
CTGCCCTTGGCGACCTTCAGGACGTTGATATCCTGATTTACCAACCGACTGAAAAATACCAGAACGTTGCCAAAAGCACT
GGCGTAAAAAAGCTCACTCCCGCCAGAGCCGCCATCGCTGAACTGGTGCGTCGCTACTGGGTATTGGGGATGGAGTGCAG
CCTACTGGAAATCCAGAAACTGGCCTGGCTGTTACAACGCGCCATTGAGCAGCATCAACAGGACGATATCCTCAAACTGC
GGTTTGAAGCTCACTATTATGGCCCCTATGCGCCCAATCTGAACCATCTGCTTAATGCGCTGGACGGCACCTATCTTAAA
GCCGAGAAACGCATCCCGGACAGCCAACCGCTGGATGTGATCTGGTTTAACGATCAGAAAAAAGAACACGTTAATGCGTA
TCTGAACAACGAAGCCAGAGAGTGGCTACCTGCGCTGGAGCAGGTCAGCCAGTTAATTGACGGCTTTGAATCGCCGTTTG
GTCTGGAGTTGCTGGCAACCGTAGACTGGTTGCTGAGCCGTGGCGAATGTCAACCAACGCTGGATTCCGTTAAGGAAGGG
CTGCACCAGTGGCCTGCGGGCGAACGCTGGGCCAGCCGTAAGTTGAGGCTGTTTGATAATAATAATCTGCAATTTGCCAT
TAACCGCGTAATGGAGTTCCATTGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References