Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-couple_hipB
Location 10311222..10311901 Replicon chromosome
Accession NZ_CP073720
Organism Dactylosporangium fulvum strain NRRL B-16292

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag Dfulv_RS47535 Protein ID WP_259860375.1
Coordinates 10311222..10311587 (+) Length 122 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag Dfulv_RS47540 Protein ID WP_259860376.1
Coordinates 10311584..10311901 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
Dfulv_RS47500 (Dfulv_47500) 10306315..10307811 + 1497 WP_259860371.1 phytoene desaturase family protein -
Dfulv_RS47505 (Dfulv_47505) 10307808..10308344 + 537 WP_259860372.1 isopentenyl-diphosphate Delta-isomerase -
Dfulv_RS47510 (Dfulv_47510) 10308341..10309213 + 873 WP_259860373.1 MerR family transcriptional regulator -
Dfulv_RS47515 (Dfulv_47515) 10309399..10310292 + 894 WP_259860374.1 polysaccharide deacetylase family protein -
Dfulv_RS47535 (Dfulv_47535) 10311222..10311587 + 366 WP_259860375.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
Dfulv_RS47540 (Dfulv_47540) 10311584..10311901 + 318 WP_259860376.1 helix-turn-helix transcriptional regulator Antitoxin
Dfulv_RS47545 (Dfulv_47545) 10312353..10312541 + 189 WP_259860377.1 type II toxin-antitoxin system HicA family toxin -
Dfulv_RS47550 (Dfulv_47550) 10312556..10312771 + 216 WP_259860378.1 type II toxin-antitoxin system HicB family antitoxin -
Dfulv_RS47555 (Dfulv_47555) 10313127..10313705 + 579 WP_259860379.1 NUDIX domain-containing protein -
Dfulv_RS47560 (Dfulv_47560) 10313969..10314682 - 714 WP_259860380.1 AIM24 family protein -
Dfulv_RS47565 (Dfulv_47565) 10314752..10315480 - 729 WP_259860381.1 AIM24 family protein -
Dfulv_RS47570 (Dfulv_47570) 10315578..10315925 - 348 WP_259869648.1 metallopeptidase family protein -
Dfulv_RS47575 (Dfulv_47575) 10315979..10316404 - 426 WP_259860382.1 OsmC family protein -
Dfulv_RS47580 (Dfulv_47580) 10316502..10316675 + 174 WP_259860383.1 hypothetical protein -
Dfulv_RS47585 (Dfulv_47585) 10316675..10316797 + 123 WP_259860384.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(37-87)


Sequences

Toxin        


Download         Length: 122 a.a.        Molecular weight: 13806.70 Da        Isoelectric Point: 5.2723

>T200129 WP_259860375.1 NZ_CP073720:10311222-10311587 [Dactylosporangium fulvum]
VTTSEWDIYVVNEVREWIRSLDPATKRRVVEAIDVLAERGPGLGRPLVDSIAHSSIVNLKELRPGTVRILFVFDPWRSSI
LLVGGDKAGRWDAWYLEAIPLAEQRYETYLKERAQEEGGRS

Download         Length: 366 bp

>T200129 NZ_CP097716:224485-224592 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11331.80 Da        Isoelectric Point: 5.6454

>AT200129 WP_259860376.1 NZ_CP073720:10311584-10311901 [Dactylosporangium fulvum]
VSSYMRWSDIRDELVEQVGGEEVVAAGKEELLAAVIGHRLAEVRKSRGLTQQEVADRMGVTKGRVSQIEQGKVSGHDVIA
RFAAALGGRLHQAIYFDDGDIAAIA

Download         Length: 318 bp

>AT200129 NZ_CP097716:c224436-224373 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References