Detailed information of TA system TA200126

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4059302..4059560
• Replicon: chromosome
• Accession: NZ_CP073719
• Organism: Escherichia coli strain CX12

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: J6O05_RS20120
• Protein ID: WP_000809168.1
• Coordinates: 4059408..4059560 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4059302..4059359 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
J6O05_RS20100	4054327..4055681	+	1355	Protein_3934	fimbria/pilus outer membrane usher protein	-
J6O05_RS20105	4055694..4056653	+	960	WP_000871671.1	hypothetical protein	-
J6O05_RS20110	4056691..4057590	-	900	WP_001300855.1	transcriptional activator NhaR	-
J6O05_RS20115	4057656..4058822	-	1167	WP_057107799.1	Na+/H+ antiporter NhaA	-
-	4059302..4059359	-	58	-	-	Antitoxin
J6O05_RS20120	4059408..4059560	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
J6O05_RS20125	4059664..4060794	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
J6O05_RS20130	4060883..4062799	-	1917	WP_000516135.1	molecular chaperone DnaK	-
J6O05_RS20135	4063192..4063889	+	698	WP_094096600.1	IS1-like element IS1A family transposase	-
J6O05_RS20140	4063953..4064357	+	405	WP_000843559.1	DUF2541 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T200126 WP_000809168.1 NZ_CP073719:4059408-4059560 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T200126 NZ_CP097713:c116988-116710 [Escherichia coli]
ATGGAGATATTCTGGACCATGCTGGCCAGCCAGGACAGGAAGCGCATTCGTGAGTACATTGCGGAGCAGAACCTGATGGC
CGCCATTGAACTGGACGAACGGATTGGTTATTCAGCCAGCAGCCTGGCCGGGCAGCCGTATAAAGGCCGCAACGGTCGTG
TGGAAGGTACCCGGGAACTGGTTATTCACCCGCATTTTGTTCTGGTTTATGAGGTCGACAGCCAGTGGGGAAAAGTGTAT
ATCCTGCGCGTGTTGCATACTGCACAGAAGTGGCCATAG

Antitoxin

Nucleotide

• Length: 58 bp

>AT200126 NZ_CP073719:c4059359-4059302 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin